Transcription Factor
| Accessions: | HXA10_HUMAN (HOCOMOCO 10), P31260 (JASPAR 2024) |
| Names: | Homeobox protein Hox-1.8, Homeobox protein Hox-1H, Homeobox protein Hox-A10, HXA10_HUMAN, PL |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P31260 |
| Length: | 410 |
| Pfam Domains: | 337-393 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSARKGYLLPSPNYPTTMSCSESPAANSFLVDSLISSGRGEAGGGGGGAGGGGGGGYYAH 60 61 GGVYLPPAADLPYGLQSCGLFPTLGGKRNEAASPGSGGGGGGLGPGAHGYGPSPIDLWLD 120 121 APRSCRMEPPDGPPPPPQQQPPPPPQPPQPAPQATSCSFAQNIKEESSYCLYDSADKCPK 180 181 VSATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLSQAYGTAKGYGSGGGGAQQLGAGP 240 241 FPAQPPGRGFDLPPALASGSADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAE 300 301 ELSPAPSESSKASPEKDSLGNSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMY 360 361 LTRERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNRENRIRELTANFNFS |
| Interface Residues: | 337, 338, 339, 340, 378, 379, 381, 382, 385, 386, 389, 390, 393 |
| 3D-footprint Homologues: | 5zfz_A, 1puf_A, 1ig7_A, 3cmy_A, 6a8r_A, 6m3d_C, 1fjl_B, 2h1k_B, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 3lnq_A, 7q3o_C, 2ld5_A, 6es3_K, 1b72_A, 3rkq_B, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 5hod_A, 2hos_A, 1au7_A, 5jlw_D, 4xrs_G, 3a01_E, 7psx_B, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 6fqp_B, 1mnm_C, 1du0_A, 6fqq_E, 3d1n_M, 4qtr_D, 1k61_B, 1o4x_A |
| Binding Motifs: | MA0899.1 rgymATWAAaa HXA10_HUMAN.H10MO.C|M01234 kayrrTTTATGw MA0899.2 gymATWAAa |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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