Transcription Factor

Accessions: UP00230A (UniPROBE 20160601)
Names: distal-less homeobox 5, Dlx5, Homeobox protein DLX-5
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: P70396
Description: distal-less homeobox 5
Length: 93
Pfam Domains: 17-73 Homeobox domain
Sequence:
(in bold interface residues)
1 VAEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQV 60
61 KIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMA
Interface Residues: 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73
3D-footprint Homologues: 1puf_A, 1fjl_B, 5zjt_E, 3cmy_A, 1ig7_A, 6a8r_A, 3d1n_M, 5zfz_A, 2h1k_B, 1nk2_P, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 7psx_B, 1b72_A, 5hod_A, 3rkq_B, 2r5y_A, 2hos_A, 5jlw_D, 4cyc_A, 1jgg_B, 4xrs_G, 4j19_B, 3a01_E, 1au7_A, 5flv_I, 1le8_A, 2xsd_C, 7xrc_C, 1e3o_C, 8g87_X, 4qtr_D, 1puf_B, 4xrm_B, 1du0_A, 3l1p_A, 1o4x_A, 1k61_B
Binding Motifs: UP00230A_1 ssrgyAATTrsykmts
Binding Sites: GGTAATTA
AATAATTA
AATTAATT
ACCAATTA
ACTAATTA
AGTAATTA
ATAATTAC
ATAATTAG
ATAATTGC
ATAATTGG
ATTAATTA
CAATTATC
CTAATTAC
CTAATTAG
GATAATTA
GCAATTAA
GCTAATTA
GTAATTAC
TAATTATA
TAATTGCA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.