Transcription Factor
| Accessions: | HOXD3 (HT-SELEX2 May2017), P31249 (JASPAR 2024) |
| Names: | ENSG00000128652, HOXD3, Homeobox protein Hox-4A, Homeobox protein Hox-D3, HXD3_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 432 |
| Pfam Domains: | 195-251 Homeobox domain 368-430 Domain of unknown function (DUF4074) |
| Sequence: (in bold interface residues) | 1 MLFEQGQQALELPECTMQKAAYYENPGLFGGYGYSKTTDTYGYSTPHQPYPPPAAASSLD 60 61 TDYPGSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQPP 120 121 PPPPTLPPSSPTNPGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATA 180 181 GESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKI 240 241 WFQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPP 300 301 AFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGG 360 361 NFVESMAPASGPVFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQ 420 421 GRLPEAPKLTHL |
| Interface Residues: | 187, 195, 196, 197, 198, 236, 237, 239, 240, 243, 244, 246, 247, 248, 251 |
| 3D-footprint Homologues: | 3a01_E, 3cmy_A, 5zfz_A, 1puf_A, 1fjl_B, 1nk2_P, 8ejp_B, 6a8r_A, 8pmf_A, 1ig7_A, 1jgg_B, 6m3d_C, 3lnq_A, 1zq3_P, 2lkx_A, 6es3_K, 2ld5_A, 7q3o_C, 8eml_B, 4xrs_G, 2hdd_A, 9b8u_A, 4cyc_A, 2r5y_A, 8ik5_C, 5flv_I, 2hos_A, 1au7_A, 5zjt_E, 4j19_B, 1puf_B, 8osb_E, 7psx_B, 5hod_A, 1b72_A, 5jlw_D, 3rkq_B, 7xrc_C, 1e3o_C, 1le8_A, 2xsd_C, 1o4x_A, 1du0_A, 3d1n_M, 8bx1_A, 4qtr_D |
| Binding Motifs: | HOXD3_3 / MA0912.2 CTAATTAc HOXD3_methyl_1 CTAATKAC HOXD3_methyl_2 gTCrTTAr |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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