Transcription Factor
| Accessions: | FOXA1_HUMAN (HOCOMOCO 10), P55317 (JASPAR 2024) |
| Names: | Forkhead box protein A1, FOXA1_HUMAN, Hepatocyte nuclear factor 3-alpha, HNF-3-alpha, HNF-3A, TCF-3A, Transcription factor 3A |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P55317 |
| Length: | 472 |
| Pfam Domains: | 17-169 Forkhead N-terminal region 170-265 Fork head domain 397-461 HNF3 C-terminal domain |
| Sequence: (in bold interface residues) | 1 MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMT 60 61 PASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQ 120 121 AASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLIT 180 181 MAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGK 240 241 GSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGA 300 301 SNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPI 360 361 SSGPGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAY 420 421 EQALQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS |
| Interface Residues: | 160, 162, 164, 165, 167, 213, 215, 216, 217, 219, 220, 221, 223, 224, 233, 240, 265 |
| 3D-footprint Homologues: | 7yz7_A, 7yzb_A, 7vox_H, 2hdc_A, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 6el8_A, 7tdx_A, 3l2c_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 3qrf_G |
| Binding Motifs: | FOXA1_HUMAN.H10MO.A|M01142 aTrTTTACwywgy MA0148.1 TGTTTrCwywg MA0148.2 TGTTTrCwywg MA0148.3 tycwTRTTTACwywg MA0148.4 awGTAAACATdw MA0148.5 GTAAACAT |
| Binding Sites: | MA0148.5.16 MA0148.5.10 MA0148.5.12 / MA0148.5.14 / MA0148.5.19 / MA0148.5.4 MA0148.5.18 MA0148.1.1 MA0148.1.10 MA0148.1.11 MA0148.1.12 MA0148.1.13 MA0148.1.14 MA0148.1.15 MA0148.1.16 MA0148.1.17 MA0148.1.18 MA0148.1.19 MA0148.1.2 MA0148.1.20 MA0148.1.3 MA0148.1.4 MA0148.1.5 MA0148.1.6 MA0148.1.7 MA0148.1.8 MA0148.1.9 MA0148.3.1 MA0148.3.10 MA0148.3.11 MA0148.3.12 MA0148.3.13 MA0148.3.14 MA0148.3.15 MA0148.3.16 MA0148.3.17 MA0148.3.18 MA0148.3.19 MA0148.3.2 / MA0148.3.3 MA0148.3.20 MA0148.3.4 MA0148.3.5 MA0148.3.6 MA0148.3.7 MA0148.3.8 MA0148.3.9 MA0148.4.16 MA0148.4.1 MA0148.4.10 MA0148.4.11 / MA0148.4.6 MA0148.4.12 MA0148.4.13 MA0148.4.14 MA0148.4.15 / MA0148.4.7 MA0148.4.16 MA0148.4.17 MA0148.4.18 MA0148.4.19 / MA0148.4.9 MA0148.4.1 / MA0148.4.2 MA0148.4.10 / MA0148.4.20 MA0148.4.2 / MA0148.4.3 MA0148.4.4 MA0148.4.5 MA0148.4.6 MA0148.4.3 / MA0148.4.7 MA0148.4.4 / MA0148.4.8 MA0148.4.5 / MA0148.4.9 MA0148.4.11 MA0148.4.12 MA0148.4.13 MA0148.4.14 MA0148.4.15 MA0148.4.17 MA0148.4.18 MA0148.4.19 MA0148.4.20 MA0148.4.8 MA0148.5.1 MA0148.5.11 / MA0148.5.3 MA0148.5.13 / MA0148.5.15 MA0148.5.17 MA0148.5.2 / MA0148.5.5 MA0148.5.20 MA0148.5.6 MA0148.5.7 MA0148.5.8 MA0148.5.9 |
| Publications: | Zhang Y, Liu T, Meyer C.A, Eeckhoute J, Johnson D.S, Bernstein B.E, Nusbaum C, Myers R.M, Brown M, Li W, Liu X.S. Model-based analysis of ChIP-Seq (MACS). Genome biology 9:R137 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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