Transcription Factor
| Accessions: | T049199_1.02 (CISBP 1.02), UP00400A (UniPROBE 20160601), EGR1_MOUSE (HOCOMOCO 10), P08046 (JASPAR 2024) |
| Names: | Egr1, T049199_1.02;, A530045N19Rik, early growth response 1, Early growth response protein 1, egr, Egr-1, ETR103, Krox-1, Krox-24, Krox-24 protein, Krox24, Nerve growth factor-induced protein A, NGF1-A, NGFI-A, NGFIA, TIS8, Transcription factor Zif268, Zenk, Zfp-6, Zif268, EGR1_MOUSE, Zinc finger protein Krox-24 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, HOCOMOCO 10 3, JASPAR 2024 4 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 4 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Transcription factor Zif268 |
| Notes: | experiment type:PBM, family:C2H2 ZF |
| Length: | 533 |
| Pfam Domains: | 132-217 Domain of unknown function (DUF3446) 336-360 C2H2-type zinc finger 336-360 Zinc finger, C2H2 type 353-376 Zinc-finger double domain 366-388 C2H2-type zinc finger 366-388 Zinc finger, C2H2 type 380-404 Zinc-finger double domain 394-412 C2H2-type zinc finger 394-416 Zinc finger, C2H2 type 424-520 Domain of unknown function (DUF3432) |
| Sequence: (in bold interface residues) | 1 MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGG 60 61 NSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKAMVETSYPS 120 121 QTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSS 180 181 SASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPA 240 241 TKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQ 300 301 DLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIH 360 361 TGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQK 420 421 DKKADKSVVASPAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGF 480 481 PSPSVATTFASVPPAFPTQVSSFPSAGVSSSFSTSTGLSDMTATFSPRTIEIC |
| Interface Residues: | 318, 322, 325, 348, 349, 350, 351, 352, 354, 355, 374, 376, 377, 378, 379, 380, 381, 382, 383, 384, 404, 405, 406, 407, 408, 409, 410, 411, 412, 415 |
| 3D-footprint Homologues: | 8ssq_A, 7w1m_H, 8ssu_A, 5kkq_D, 5ei9_F, 7ysf_A, 6jnm_A, 2kmk_A, 1tf3_A, 7n5w_A, 2jpa_A, 1mey_C, 5und_A, 1f2i_J, 5k5i_A, 6ml4_A, 2gli_A, 1g2f_F, 6blw_A, 1tf6_A, 6u9q_A, 5yel_A, 4x9j_A, 2i13_A, 5kl3_A, 1ubd_C, 6wmi_A, 7eyi_G, 5v3j_F, 8h9h_G, 2lt7_A, 6e94_A, 6a57_A, 2drp_D, 3uk3_C, 8cuc_F, 7y3l_A, 7txc_E, 1llm_D, 2wbs_A, 4m9v_C, 7y3m_I, 8gn3_A, 5yj3_D |
| Binding Motifs: | PB0010.1 yCCGCCCMCgCayt PB0114.1 kkybGaGkGGGAywrk UP00400A_1 sakmkgmCgCCCmCGCAytrtym M0417_1.02 tgmGkGGGcg M0418_1.02 atgCGkGGG EGR1_MOUSE.H10MO.A|M01061 kGCGkGGGCGg MA0162.1 yGCGTGGGcGk |
| Binding Sites: | CCGCCCCC ACCCACGC ACCCCCGC ACGCCCAC ACGCCCCC CCCACGCA CCCACGCG CCCCCGCA CCCCCGCC CCGCCCAC CGCCCACC CGCCCACG CGCCCCCA CGCCCCCG CGGGGGCA CGTGGGCA GCCCACGC GCCCCCGC GCGGGGGA GCGTGGGA MA0162.1.1 MA0162.1.10 MA0162.1.11 MA0162.1.12 MA0162.1.13 MA0162.1.14 MA0162.1.15 MA0162.1.2 MA0162.1.3 / MA0162.1.4 MA0162.1.5 MA0162.1.6 MA0162.1.7 MA0162.1.8 MA0162.1.9 |
| Publications: | Berger M.F, Philippakis A.A, Qureshi A.M, He F.S, Estep P.W, Bulyk M.L. Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nature biotechnology 24:1429-35 (2006). [Pubmed] Meng X, Brodsky M.H, Wolfe S.A. A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors. Nature biotechnology 23:988-94 (2005). [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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