Transcription Factor

Accessions: 4p9u_F (3D-footprint 20231221)
Names: FADR_VIBCH, Fatty acid metabolism regulator protein
Organisms: strain ATCC 39315 / El Tor Inaba N16961, Vibrio cholerae serotype O1
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q9KQU8
Length: 272
Pfam Domains: 7-66 Bacterial regulatory proteins, gntR family
67-269 FadR C-terminal domain
Sequence:
(in bold interface residues)
1 KSPAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQH 60
61 GKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAE 120
121 RIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKTFNFYD 180
181 YMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVCQSGER 240
241 EHLPQVIRQYGIASGHIWNQMKMTLPSNFTED
Interface Residues: 28, 29, 30, 33, 39, 40, 41, 42, 43, 44, 45, 46, 59, 60, 65, 66, 181, 209
3D-footprint Homologues: 6wg7_G, 7b5y_B, 4wwc_B, 7zla_B, 4h0e_A, 4p9u_F, 6za3_B, 4u0y_B, 1h9t_B, 3mzh_A, 3zpl_B, 4fx4_B, 2gli_A
Binding Motifs: 4p9u_F TnaCCa
Binding Sites: 4p9u_G
4p9u_H
Publications: Shi W, Kovacikova G, Lin W, Taylor R.K, Skorupski K, Kull F.J. The 40-residue insertion in Vibrio cholerae FadR facilitates binding of an additional fatty acyl-CoA ligand. Nature communications 6:6032 (2015). [Pubmed]
Related annotations: PaperBLAST

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