Transcription Factor

Accessions: T084792_1.02 (CISBP 1.02), GATA3_MOUSE (HOCOMOCO 10), P23772 (JASPAR 2024)
Names: Gata3, T084792_1.02;, GATA-binding factor 3, GATA3_MOUSE, Trans-acting T-cell-specific transcription factor GATA-3
Organisms: Mus musculus
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:GATA
Length: 443
Pfam Domains: 263-296 GATA zinc finger
317-349 GATA zinc finger
Sequence:
(in bold interface residues)
1 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMEAQYPLTEEVDVLFNIDGQGNHVP 60
61 SYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALSSHHTASPWNLSPFSKTS 120
121 IHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEK 180
181 ECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLG 240
241 GSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL 300
301 IKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEG 360
361 IQTRNRKMSSKSKKCKKVHDALEDFPKSSSFNPAALSRHMSSLSHISPFSHSSHMLTTPT 420
421 PMHPPSGLSFGPHHPSSMVTAMG
Interface Residues: 272, 273, 275, 285, 289, 326, 327, 329, 339, 343, 344, 347, 363, 364, 366, 367
3D-footprint Homologues: 4hc9_A, 3vd6_C, 3dfx_B, 1gat_A, 4gat_A, 6cnb_R
Binding Motifs: PB0125.1 ytwtrywGATtktATCrrbwhm
M0783_1.02 wwswGATaas
GATA3_MOUSE.H10MO.C|M01119 sAGATArr
PB0021.1 bkwdwakAGATAAGArwtdarg
MA0037.4 dwtCTTATCTbh
MA0037.5 tCTTATCT
Binding Sites: MA0037.5.9
MA0037.5.13 / MA0037.5.14 / MA0037.5.5
MA0037.4.1
MA0037.4.10
MA0037.4.11 / MA0037.4.14
MA0037.4.12 / MA0037.4.17
MA0037.4.13 / MA0037.4.18
MA0037.4.14 / MA0037.4.19
MA0037.4.15 / MA0037.4.20
MA0037.4.16 / MA0037.4.19
MA0037.4.17
MA0037.4.18
MA0037.4.2 / MA0037.4.3
MA0037.4.20
MA0037.4.3 / MA0037.4.5
MA0037.4.4 / MA0037.4.7
MA0037.4.5 / MA0037.4.8
MA0037.4.6 / MA0037.4.9
MA0037.4.10 / MA0037.4.7
MA0037.4.11 / MA0037.4.8
MA0037.4.12 / MA0037.4.9
MA0037.4.13
MA0037.4.15
MA0037.4.16
MA0037.4.2
MA0037.4.4
MA0037.4.6
MA0037.5.1
MA0037.5.10
MA0037.5.11
MA0037.5.12 / MA0037.5.18
MA0037.5.15 / MA0037.5.2 / MA0037.5.6 / MA0037.5.7
MA0037.5.16 / MA0037.5.17 / MA0037.5.19
MA0037.5.20 / MA0037.5.3
MA0037.5.4
MA0037.5.8
Publications: Merika M., Orkin S. H. DNA-binding specificity of GATA family transcription factors. Mol. Cell. Biol. 13:3999-4010 (1993). [Pubmed]

Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

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