Transcription Factor
| Accessions: | T084792_1.02 (CISBP 1.02), GATA3_MOUSE (HOCOMOCO 10), P23772 (JASPAR 2024) |
| Names: | Gata3, T084792_1.02;, GATA-binding factor 3, GATA3_MOUSE, Trans-acting T-cell-specific transcription factor GATA-3 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:GATA |
| Length: | 443 |
| Pfam Domains: | 263-296 GATA zinc finger 317-349 GATA zinc finger |
| Sequence: (in bold interface residues) | 1 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMEAQYPLTEEVDVLFNIDGQGNHVP 60 61 SYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALSSHHTASPWNLSPFSKTS 120 121 IHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEK 180 181 ECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLG 240 241 GSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL 300 301 IKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEG 360 361 IQTRNRKMSSKSKKCKKVHDALEDFPKSSSFNPAALSRHMSSLSHISPFSHSSHMLTTPT 420 421 PMHPPSGLSFGPHHPSSMVTAMG |
| Interface Residues: | 272, 273, 275, 285, 289, 326, 327, 329, 339, 343, 344, 347, 363, 364, 366, 367 |
| 3D-footprint Homologues: | 4hc9_A, 3vd6_C, 3dfx_B, 1gat_A, 4gat_A, 6cnb_R |
| Binding Motifs: | PB0125.1 ytwtrywGATtktATCrrbwhm M0783_1.02 wwswGATaas GATA3_MOUSE.H10MO.C|M01119 sAGATArr PB0021.1 bkwdwakAGATAAGArwtdarg MA0037.4 dwtCTTATCTbh MA0037.5 tCTTATCT |
| Binding Sites: | MA0037.5.9 MA0037.5.13 / MA0037.5.14 / MA0037.5.5 MA0037.4.1 MA0037.4.10 MA0037.4.11 / MA0037.4.14 MA0037.4.12 / MA0037.4.17 MA0037.4.13 / MA0037.4.18 MA0037.4.14 / MA0037.4.19 MA0037.4.15 / MA0037.4.20 MA0037.4.16 / MA0037.4.19 MA0037.4.17 MA0037.4.18 MA0037.4.2 / MA0037.4.3 MA0037.4.20 MA0037.4.3 / MA0037.4.5 MA0037.4.4 / MA0037.4.7 MA0037.4.5 / MA0037.4.8 MA0037.4.6 / MA0037.4.9 MA0037.4.10 / MA0037.4.7 MA0037.4.11 / MA0037.4.8 MA0037.4.12 / MA0037.4.9 MA0037.4.13 MA0037.4.15 MA0037.4.16 MA0037.4.2 MA0037.4.4 MA0037.4.6 MA0037.5.1 MA0037.5.10 MA0037.5.11 MA0037.5.12 / MA0037.5.18 MA0037.5.15 / MA0037.5.2 / MA0037.5.6 / MA0037.5.7 MA0037.5.16 / MA0037.5.17 / MA0037.5.19 MA0037.5.20 / MA0037.5.3 MA0037.5.4 MA0037.5.8 |
| Publications: | Merika M., Orkin S. H. DNA-binding specificity of GATA family transcription factors. Mol. Cell. Biol. 13:3999-4010 (1993). [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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