Transcription Factor

Accessions: TFCP2 (HT-SELEX2 May2017)
Names: ENSG00000135457, TFCP2
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: CP2 experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: CP2 experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4
Length: 258
Pfam Domains: 34-240 CP2 transcription factor
Sequence:
(in bold interface residues)
1 FDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDNENKILPFQYVLCAATSPAVKL 60
61 HDETLTYLNQGQSYEIRMLDNRKLGELPEINGKLVKSIFRVVFHDRRLQYTEHQQLEGWR 120
121 WNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPAKRTSVFIQVHCISTEFTMRKH 180
181 GGEKGVPFRVQIDTFKENENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTPHE 240
241 KEKYQPSYETTILTECSP
Interface Residues: 167, 169, 171, 191, 193, 195, 200, 219, 224, 227
3D-footprint Homologues: 7cuh_A, 5mpf_B
Binding Motifs: TFCP2_2 aaCyrGttyrawCyrGwt
TFCP2_4 wACCGGTttwAACCgGwT
TFCP2_methyl_1 awCyrGwtyrawCyrGwt
TFCP2_methyl_3 AWCCGGTTyrAwCCGGTT
Related annotations: PaperBLAST

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