Transcription Factor
| Accessions: | ZNF454 (HT-SELEX2 May2017) |
| Names: | ENSG00000178187, ZNF454 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: KRAB_Znf_C2H2 experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: KRAB_Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 362 |
| Pfam Domains: | 18-40 Zinc finger, C2H2 type 18-38 C2H2-type zinc finger 18-40 C2H2-type zinc finger 33-66 Zinc-finger double domain 56-78 Zinc finger, C2H2 type 56-72 C2H2-type zinc finger 56-78 C2H2-type zinc finger 74-94 Zinc-finger double domain 83-104 C2H2-type zinc finger 84-106 C2H2-type zinc finger 84-106 Zinc finger, C2H2 type 98-121 Zinc-finger double domain 112-134 Zinc finger, C2H2 type 112-121 C2H2-type zinc finger 127-151 Zinc-finger double domain 140-162 C2H2-type zinc finger 154-178 Zinc-finger double domain 167-188 C2H2-type zinc finger 168-190 C2H2-type zinc finger 168-190 Zinc finger, C2H2 type 183-205 Zinc-finger double domain 195-216 C2H2-type zinc finger 196-218 C2H2-type zinc finger 196-218 Zinc finger, C2H2 type 210-233 Zinc-finger double domain 223-244 C2H2-type zinc finger 224-246 C2H2-type zinc finger 224-246 Zinc finger, C2H2 type 239-261 Zinc-finger double domain 252-272 C2H2-type zinc finger 252-274 C2H2-type zinc finger 252-274 Zinc finger, C2H2 type 266-290 Zinc-finger double domain 279-300 C2H2-type zinc finger 280-302 Zinc finger, C2H2 type 280-302 C2H2-type zinc finger 294-317 Zinc-finger double domain 307-326 C2H2-type zinc finger 308-330 Zinc finger, C2H2 type 308-330 C2H2-type zinc finger 322-346 Zinc-finger double domain 335-358 C2H2-type zinc finger 336-358 C2H2-type zinc finger 336-358 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 SSLHSDQSQGFQPSKNAFECSECGKVFSKSSTLNKHQKIHNEKNANQKIHIKEKRYECRE 60 61 CGKAFHQSTHLIHHQRIHTGEKPYECKECGKAFSVSSSLTYHQKIHTGEKPFECNLCGKA 120 121 FIRNIHLAHHHRIHTGEKPFKCNICEKAFVCRAHLTKHQNIHSGEKPYKCNECGKAFNQS 180 181 TSFLQHQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPYKCNECGKAFRDNSSFA 240 241 RHRKIHTGEKPYRCGLCEKAFRDQSALAQHQRIHTGEKPYTCNICEKAFSDHSALTQHKR 300 301 IHTREKPYKCKICEKAFIRSTHLTQHQRIHTGEKPYKCNKCGKAFNQTANLIQHQRHHIG 360 361 EK |
| Interface Residues: | 29, 31, 32, 66, 67, 69, 70, 72, 73, 75, 76, 79, 94, 95, 97, 98, 101, 105, 122, 123, 124, 125, 126, 128, 129, 132, 151, 152, 153, 154, 156, 157, 161, 178, 179, 180, 181, 182, 185, 196, 206, 207, 208, 209, 210, 212, 213, 214, 217, 234, 235, 236, 237, 238, 239, 240, 241, 242, 262, 263, 264, 265, 266, 268, 269, 291, 292, 293, 294, 296, 297, 303, 317, 318, 319, 320, 321, 322, 325, 329, 346, 347, 348, 349, 350, 352, 353 |
| 3D-footprint Homologues: | 5k5l_F, 1tf3_A, 2jpa_A, 7y3l_A, 8cuc_F, 8ssu_A, 2wbs_A, 1tf6_A, 8gn3_A, 5kl3_A, 8ssq_A, 7w1m_H, 7y3m_I, 5yj3_D, 5yel_A, 5v3j_F, 2lt7_A, 6jnm_A, 2gli_A, 5ei9_F, 1g2f_F, 7txc_E, 2kmk_A, 3uk3_C, 5kkq_D, 4m9v_C, 6e94_A, 7ysf_A, 1ubd_C, 6ml4_A, 6u9q_A, 7n5w_A, 5k5i_A, 6blw_A, 1f2i_J, 2drp_D, 4x9j_A, 8h9h_G, 6a57_A, 1llm_D |
| Binding Motifs: | ZNF454_3 TrGCGCCGGCGCyw ZNF454_4 trGCGCCwGGCGCya ZNF454_methyl_1 TrGCGCCGGCGCyw ZNF454_methyl_2 wrGCGCCwGGCGCyw |
| Related annotations: | PaperBLAST |
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