Transcription Factor
| Accessions: | NANOG_MOUSE (HOCOMOCO 10), Q80Z64 (JASPAR 2024) |
| Names: | Early embryo specific expression NK-type homeobox protein, ES cell-associated protein 4, Homeobox protein NANOG, Homeobox transcription factor Nanog, NANOG_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q80Z64 |
| Length: | 305 |
| Pfam Domains: | 98-153 Homeobox domain 111-147 Homeodomain leucine-zipper encoding, Homez |
| Sequence: (in bold interface residues) | 1 MSVGLPGPHSLPSSEEASNSGNASSMPAVFHPENYSCLQGSATEMLCTEAASPRPSSEDL 60 61 PLQGSPDSSTSPKQKLSSPEADKGPEEEENKVLARKQKMRTVFSQAQLCALKDRFQKQKY 120 121 LSLQQMQELSSILNLSYKQVKTWFQNQRMKCKRWQKNQWLKTSNGLIQKGSAPVEYPSIH 180 181 CSYPQGYLVNASGSLSMWGSQTWTNPTWSSQTWTNPTWNNQTWTNPTWSSQAWTAQSWNG 240 241 QPWNAAPLHNFGEDFLQPYVQLQQNFSASDLEVNLEATRESHAHFSTPQALELFLNYSVT 300 301 PPGEI |
| Interface Residues: | 97, 98, 99, 100, 138, 139, 141, 142, 145, 146, 149, 150, 153 |
| 3D-footprint Homologues: | 1fjl_B, 3cmy_A, 2h1k_B, 1ig7_A, 5zfz_A, 1puf_A, 3d1n_M, 6a8r_A, 1zq3_P, 3lnq_A, 1nk2_P, 2lkx_A, 1jgg_B, 7q3o_C, 2ld5_A, 6es3_K, 3a01_E, 5jlw_D, 1au7_A, 4xrs_G, 3rkq_B, 1b72_A, 6m3d_C, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 7psx_B, 5hod_A, 3l1p_A, 2hos_A, 7xrc_C, 1le8_A, 8g87_X, 1puf_B, 1du0_A, 4qtr_D |
| Binding Motifs: | NANOG_MOUSE.H10MO.A|M01223 kyywTTswtATGywAAt UN0383.1 waACAATGgaa MA2339.1 GCAATCA |
| Binding Sites: | MA2339.1.13 UN0383.1.13 UN0383.1.1 UN0383.1.10 UN0383.1.11 UN0383.1.12 UN0383.1.14 UN0383.1.15 UN0383.1.16 UN0383.1.17 UN0383.1.18 UN0383.1.19 UN0383.1.2 UN0383.1.20 UN0383.1.3 UN0383.1.4 UN0383.1.5 UN0383.1.6 UN0383.1.7 UN0383.1.8 UN0383.1.9 MA2339.1.18 / MA2339.1.3 MA2339.1.1 / MA2339.1.12 / MA2339.1.16 / MA2339.1.9 MA2339.1.10 MA2339.1.11 MA2339.1.14 / MA2339.1.20 MA2339.1.15 / MA2339.1.17 / MA2339.1.7 / MA2339.1.8 MA2339.1.19 MA2339.1.2 MA2339.1.4 MA2339.1.5 MA2339.1.6 |
| Publications: | Avsec Z, Weilert M, Shrikumar A, Krueger S, Alexandari A, Dalal K, Fropf R, McAnany C, Gagneur J, Kundaje A, Zeitlinger J. Base-resolution models of transcription-factor binding reveal soft motif syntax. Nat Genet 53:354-366 (2021). [Pubmed] |
| Related annotations: | PaperBLAST |
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