Transcription Factor
| Accessions: | NKX25_MOUSE (HOCOMOCO 10), P42582 (JASPAR 2024) |
| Names: | Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX25_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 318 |
| Pfam Domains: | 138-194 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MFPSPALTPTPFSVKDILNLEQQQRSLASGDLSARLEATLAPASCMLAAFKPEAYSGPEA 60 61 AASGLAELRAEMGPAPSPPKCSPAFPAAPTFYPGAYGDPDPAKDPRADKKELCALQKAVE 120 121 LDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQ 180 181 VKIWFQNRRYKCKRQRQDQTLELLGPPPPPARRIAVPVLVRDGKPCLGDPAAYAPAYGVG 240 241 LNAYGYNAYPYPSYGGAACSPGYSCAAYPAAPPAAQPPAASANSNFVNFGVGDLNTVQSP 300 301 GMPQGNSGVSTLHGIRAW |
| Interface Residues: | 137, 138, 139, 140, 141, 179, 180, 182, 183, 186, 187, 190, 191, 194 |
| 3D-footprint Homologues: | 4j19_B, 1fjl_B, 5zjt_E, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 1puf_B, 5zfz_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 3rkq_B, 2hdd_A, 5jlw_D, 4cyc_A, 2r5y_A, 1jgg_B, 4xrs_G, 2hos_A, 1au7_A, 5flv_I, 3lnq_A, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1o4x_A, 4qtr_D, 4xrm_B, 1mnm_C, 1du0_A, 3l1p_A, 1k61_B |
| Binding Motifs: | MA0503.1 arsCWCTCAas NKX25_MOUSE.H10MO.C|M01246 tyAAGTG MA0063.1 wTAAktg PH0114.1 hrakCCACTTrAawty |
| Binding Sites: | MA0063.1.1 MA0063.1.10 MA0063.1.11 MA0063.1.12 MA0063.1.13 MA0063.1.14 MA0063.1.15 MA0063.1.16 MA0063.1.17 MA0063.1.2 MA0063.1.3 MA0063.1.4 MA0063.1.5 MA0063.1.6 MA0063.1.7 MA0063.1.8 MA0063.1.9 MA0503.1.1 MA0503.1.10 MA0503.1.11 MA0503.1.12 MA0503.1.13 MA0503.1.14 MA0503.1.15 MA0503.1.16 MA0503.1.17 MA0503.1.18 MA0503.1.19 MA0503.1.2 MA0503.1.20 MA0503.1.3 MA0503.1.4 MA0503.1.5 MA0503.1.6 MA0503.1.7 MA0503.1.8 MA0503.1.9 |
| Publications: | Chen C. Y., Schwartz R. J. Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5. J. Biol. Chem. 270:15628-15633 (1995). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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