Transcription Factor
| Accessions: | Q9NQV7 (JASPAR 2024) |
| Names: | [histone H3]-lysine36 N-trimethyltransferase PRDM9, [histone H3]-lysine4 N-trimethyltransferase PRDM9, [histone H3]-lysine9 N-trimethyltransferase PRDM9, [histone H4]-lysine20 N-methyltransferase PRDM9, [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9, EC 2.1.1.-, EC 2.1.1.354, EC 2.1.1.355, EC 2.1.1.359, EC 2.1.1.361, EC 2.1.1.362, Histone-lysine N-methyltransferase PRDM9, PR domain zinc finger protein 9, PR domain-containing protein 9, PRDM9_HUMAN, Protein-lysine N-methyltransferase PRDM9 |
| Organisms: | Homo sapiens, Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9NQV7 |
| Length: | 894 |
| Pfam Domains: | 28-62 KRAB box 170-202 SSXRD motif 542-562 Zinc-finger double domain 552-574 Zinc finger, C2H2 type 566-590 Zinc-finger double domain 580-602 C2H2-type zinc finger 580-602 Zinc finger, C2H2 type 580-602 C2H2-type zinc finger 595-618 Zinc-finger double domain 608-630 C2H2-type zinc finger 608-630 Zinc finger, C2H2 type 608-630 C2H2-type zinc finger 623-646 Zinc-finger double domain 636-658 C2H2-type zinc finger 636-658 C2H2-type zinc finger 636-658 Zinc finger, C2H2 type 651-674 Zinc-finger double domain 664-686 C2H2-type zinc finger 664-686 C2H2-type zinc finger 664-686 Zinc finger, C2H2 type 679-702 Zinc-finger double domain 692-714 Zinc finger, C2H2 type 692-714 C2H2-type zinc finger 692-714 C2H2-type zinc finger 707-731 Zinc-finger double domain 720-742 Zinc finger, C2H2 type 720-742 C2H2-type zinc finger 720-742 C2H2-type zinc finger 734-757 Zinc-finger double domain 748-770 Zinc finger, C2H2 type 748-770 C2H2-type zinc finger 748-770 C2H2-type zinc finger 762-785 Zinc-finger double domain 776-798 C2H2-type zinc finger 776-798 Zinc finger, C2H2 type 776-798 C2H2-type zinc finger 790-815 Zinc-finger double domain 804-826 C2H2-type zinc finger 804-826 Zinc finger, C2H2 type 804-826 C2H2-type zinc finger 818-843 Zinc-finger double domain 832-854 C2H2-type zinc finger 832-854 Zinc finger, C2H2 type 832-854 C2H2-type zinc finger 846-870 Zinc-finger double domain 860-882 C2H2-type zinc finger 860-882 C2H2-type zinc finger 860-882 Zinc finger, C2H2 type 877-891 Zinc-finger double domain |
| Sequence: (in bold interface residues) | 1 MSPEKSQEESPEEDTERTERKPMVKDAFKDISIYFTKEEWAEMGDWEKTRYRNVKRNYNA 60 61 LITIGLRATRPAFMCHRRQAIKLQVDDTEDSDEEWTPRQQVKPPWMALRVEQRKHQKGMP 120 121 KASFSNESSLKELSRTANLLNASGSEQAQKPVSPSGEASTSGQHSRLKLELRKKETERKM 180 181 YSLRERKGHAYKEVSEPQDDDYLYCEMCQNFFIDSCAAHGPPTFVKDSAVDKGHPNRSAL 240 241 SLPPGLRIGPSGIPQAGLGVWNEASDLPLGLHFGPYEGRITEDEEAANNGYSWLITKGRN 300 301 CYEYVDGKDKSWANWMRYVNCARDDEEQNLVAFQYHRQIFYRTCRVIRPGCELLVWYGDE 360 361 YGQELGIKWGSKWKKELMAGREPKPEIHPCPSCCLAFSSQKFLSQHVERNHSSQNFPGPS 420 421 ARKLLQPENPCPGDQNQEQQYPDPHSRNDKTKGQEIKERSKLLNKRTWQREISRAFSSPP 480 481 KGQMGSCRVGKRIMEEESRTGQKVNPGNTGKLFVGVGISRIAKVKYGECGQGFSVKSDVI 540 541 THQRTHTGEKLYVCRECGRGFSWKSHLLIHQRIHTGEKPYVCRECGRGFSWQSVLLTHQR 600 601 THTGEKPYVCRECGRGFSRQSVLLTHQRRHTGEKPYVCRECGRGFSRQSVLLTHQRRHTG 660 661 EKPYVCRECGRGFSWQSVLLTHQRTHTGEKPYVCRECGRGFSWQSVLLTHQRTHTGEKPY 720 721 VCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRDKSHLLRHQRTHTGEKPYVCRE 780 781 CGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRG 840 841 FRNKSHLLRHQRTHTGEKPYVCRECGRGFSDRSSLCYHQRTHTGEKPYVCREDE |
| Interface Residues: | 563, 565, 569, 590, 591, 592, 593, 594, 597, 619, 620, 621, 622, 624, 625, 627, 628, 629, 631, 636, 647, 648, 649, 650, 653, 674, 675, 676, 677, 678, 681, 702, 703, 704, 705, 706, 708, 709, 730, 731, 732, 733, 734, 736, 737, 759, 760, 761, 762, 764, 765, 766, 768, 771, 785, 786, 787, 788, 789, 790, 791, 792, 793, 794, 797, 814, 815, 816, 817, 818, 820, 821, 842, 843, 845, 846, 849, 870, 871, 873, 874, 876, 877 |
| 3D-footprint Homologues: | 7w1m_H, 7n5w_A, 1llm_D, 8h9h_G, 7y3m_I, 6blw_A, 2wbs_A, 6e94_A, 2jpa_A, 2kmk_A, 5v3j_F, 8ssq_A, 5k5l_F, 5kl3_A, 6jnm_A, 4x9j_A, 8ssu_A, 1g2f_F, 5yel_A, 8cuc_F, 7y3l_A, 2gli_A, 5kkq_D, 1tf6_A, 8gn3_A, 5ei9_F, 7ysf_A, 2lt7_A, 6a57_A, 1ubd_C, 6ml4_A, 2drp_D, 5k5i_A, 4m9v_C, 1tf3_A, 6u9q_A, 1f2i_J, 5yj3_D, 7txc_E, 3uk3_C |
| Binding Motifs: | UN0260.1 rwGGcAGTAGCAcCwk MA1723.1 rGkGGgmAgGGrGGmrrmArvarr MA1723.2 rGkGGgmAgGGrGGmrrmAr |
| Binding Sites: | UN0260.1.1 UN0260.1.10 UN0260.1.11 UN0260.1.12 UN0260.1.13 UN0260.1.14 UN0260.1.15 UN0260.1.16 UN0260.1.17 UN0260.1.18 UN0260.1.19 UN0260.1.2 UN0260.1.20 UN0260.1.3 UN0260.1.4 UN0260.1.5 UN0260.1.6 UN0260.1.7 UN0260.1.8 UN0260.1.9 |
| Publications: | Altemose N, Noor N, Bitoun E, Tumian A, Imbeault M, Chapman JR, Aricescu AR, Myers SR. A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis. Elife : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.