Transcription Factor
| Accessions: | HOXA10_DBD (HumanTF 1.0), HOXA10_TF2 (HumanTF2 1.0), Hoxa10_TF1 (HumanTF2 1.0), HOXA10 (HT-SELEX2 May2017) |
| Names: | Homeobox protein Hox-1.8, Homeobox protein Hox-1H, Homeobox protein Hox-A10, HOXA10, HXA10_HUMAN, PL, HOXA10 protein, Q5I0Y5_HUMAN, ENSG00000253293 |
| Organisms: | Homo sapiens, Pantheropsis Guttatus |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P31260 |
| Notes: | Ensembl ID: ENSG00000153807; DNA-binding domain sequence; TF family: homeodomain; Clone source: MGC, Ensembl ID: ENSG00000153807; Construct type: TF2(3xFLAG); TF family: Homeodomain-Posterior; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000153807; Construct type: TF1(SBP); TF family: Homeodomain-Posterior; Clone source: Gene synthesis, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 113 |
| Pfam Domains: | 40-96 Homeobox domain |
| Sequence: (in bold interface residues) | 1 AAEELSPAPSESSKASPEKDSLGNSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLF 60 61 NMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNRENRIRELTANFNFS |
| Interface Residues: | 40, 41, 42, 43, 81, 82, 84, 85, 88, 89, 92, 93, 96 |
| 3D-footprint Homologues: | 1puf_A, 3cmy_A, 1fjl_B, 3d1n_M, 6a8r_A, 1ig7_A, 6m3d_C, 2h1k_B, 5zfz_A, 2lkx_A, 1nk2_P, 1zq3_P, 7q3o_C, 2ld5_A, 6es3_K, 3rkq_B, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 2hos_A, 1b72_A, 5jlw_D, 3lnq_A, 4xrs_G, 3a01_E, 1jgg_B, 7psx_B, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 6fqp_B, 6fqq_E, 5hod_A, 4qtr_D, 1o4x_A, 1du0_A |
| Binding Motifs: | HOXA10_DBD_1 rrTCrTWAAaww HOXA10_DBD_2 rgymATWAAaa FOXO1_HOXA10 rwmAACAycrTwAa Hoxa10_1 rRTmRTAAAAy Hoxa10_2 gGyMATWAAAh PBX4_HOXA10_1 ccATAAATCA- PBX4_HOXA10_2 vtcrTAAATCa- PBX4_HOXA10_2_3 cycrTAAATCamTCa HOXA10_3 rGTCGTAAAAh HOXA10_4 gGymATAAAAm HOXA10_7 grTCrTWAAmy HOXA10_8 gGymATWAAac HOXA10_methyl_1 gGTCGTAAAay HOXA10_methyl_2 gGymATAAAAc HOXA10_methyl_5 grTCGTWAAay HOXA10_methyl_6 sgymATWAAay |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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