Transcription Factor

						

			
Accessions: TCF7 (SMILE-seq 1.0)

			
Names: T-cell factor 1, T-cell-specific transcription factor 1, TCF-1, TCF-7, TCF7, TCF7_HUMAN, Transcription factor 7
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: P36402
Notes: TF family: HMG
Length: 383
Pfam Domains:     1-212 N-terminal CTNNB1 binding
  269-336 HMG (high mobility group) box
  270-327 Domain of unknown function (DUF1898)
Sequence: 
(in bold interface residues)		   1 MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESE   60
  61 GAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTSGMYKET  120
 121 VYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQLSLYEHFNSPHPTPAPADISQ  180
 181 KQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLGSGVPGHPAAIPHPAIVPPS  240
 241 GKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAIN  300
 301 QILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTGG  360
 361 KRNAFGTYPEKAAAPAPFLPMTV
Interface Residues: 271, 274, 276, 277, 280, 284, 295, 296, 297, 300, 338, 340, 342, 345
3D-footprint Homologues: 7m5w_A, 2gzk_A, 2lef_A
Binding Motifs: TCF7 yycTTTGATsTtt
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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