Transcription Factor

						

			
Accessions: 3laj_E (3D-footprint 20231221), 3lap_D (3D-footprint 20231221), 3lap_E (3D-footprint 20231221), 3lap_F (3D-footprint 20231221)

			
Names: Arginine repressor, ARGR_MYCTU
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P9WPY8
Length: 154
Pfam Domains:      1-69 Arginine repressor, DNA binding domain
   85-152 Arginine repressor, C-terminal domain
Sequence: 
(in bold interface residues)		   1 NRAGRQARIVAILSSAQVRSQNELAALLAAEGIEVTQATLSRDLEELGAVKLRGADGGTG   60
  61 IYVVPEDGSPVRGVSGGTDRMARLLGELLVSTDDSGNLAVLRTPPGAAHYLASAIDRAAL  120
 121 PQVVGTIAGDDTILVVAREPTTGAQLAGMFENLR
Interface Residues: 36, 37, 38, 39, 41, 42
3D-footprint Homologues: 2p5l_D, 3lap_B, 4u7b_B
Binding Motifs: 3laj_CE TGCATAnnGATGC
3lap_AD GCATCnnTATGCA
3laj_E GCaTc
3lap_BF TGCATAnnGATGC
3lap_CE TGCATAnnGATGC
Binding Sites: 3laj_G / 3lap_G / 3lap_I / 3lap_K
3laj_H / 3lap_H / 3lap_J / 3lap_L
			
Publications: Cherney L.T, Cherney M.M, Garen C.R, James M.N. Crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression. Journal of molecular biology 399:240-54 (2010). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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