Transcription Factor
| Accessions: | ZBTB26 (HT-SELEX2 May2017), Q9HCK0 (JASPAR 2024) |
| Names: | ENSG00000171448, ZBTB26, ZBT26_HUMAN, Zinc finger and BTB domain-containing protein 26, Zinc finger protein 481, Zinc finger protein Bioref |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: Znf_C2H2 experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 441 |
| Pfam Domains: | 23-123 BTB/POZ domain 273-295 C2H2-type zinc finger 273-295 Zinc finger, C2H2 type 298-320 Zinc finger, C2H2 type 299-320 C2H2-type zinc finger 312-336 Zinc-finger double domain 326-348 C2H2-type zinc finger 326-348 Zinc finger, C2H2 type 340-365 Zinc-finger double domain 354-377 Zinc finger, C2H2 type 354-377 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MSERSDLLHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRD 60 61 QFLLNDSREVKISILQSSEVGRQLLLSCYSGVLEFPEMELVNYLTAASFLQMSHIVERCT 120 121 QALWKFIKPKQPMDSKEGCEPQSASPQSKEQQGDARGSPKQDSPCIHPSEDSMDMEDSDI 180 181 QIVKVESIGDVSEVRSKKDQNQFISSEPTALHSSEPQHSLINSTVENRVSEIEQNHLHNY 240 241 ALSYTGSDNIIMASKDVFGPNIRGVDKGLQWHHQCPKCTRVFRHLENYANHLKMHKLFMC 300 301 LLCGKTFTQKGNLHRHMRVHAGIKPFQCKICGKTFSQKCSLQDHLNLHSGDKPHKCNYCD 360 361 MVFAHKPVLRKHLKQLHGKNSFDNANERNVQDLTVDFDSFACTTVTDSKGCQPQPDATQV 420 421 LDAGKLAQAVLNLRNDSTCVN |
| Interface Residues: | 283, 284, 285, 286, 287, 289, 290, 292, 293, 298, 308, 309, 310, 311, 312, 314, 315, 316, 336, 337, 338, 339, 340, 341, 342, 343, 344, 347, 364, 365, 366, 367, 368, 369, 370, 371, 375 |
| 3D-footprint Homologues: | 8ssu_A, 5kkq_D, 8ssq_A, 6ml4_A, 5v3j_F, 5yel_A, 5ei9_F, 2drp_D, 7eyi_G, 2i13_A, 6e94_A, 7ysf_A, 6wmi_A, 2jpa_A, 1ubd_C, 2kmk_A, 7y3l_A, 7n5w_A, 1tf3_A, 6jnm_A, 8cuc_F, 1tf6_A, 4x9j_A, 8gn3_A, 6blw_A, 6u9q_A, 1mey_C, 7txc_E, 5kl3_A, 1f2i_J, 5k5i_A, 7w1m_H, 5und_A, 2gli_A, 1g2f_F, 8h9h_G, 4m9v_C, 2lt7_A, 7y3m_I, 6a57_A, 3uk3_C, 5k5l_F, 1llm_D, 2wbs_A, 5yj3_D |
| Binding Motifs: | ZBTB26_2 rmTCyAGAAaar ZBTB26_methyl_1 rmTCyAGAAaaw MA1579.1 tdcTCCAGAAaarmy MA1579.2 cTCCAGAA |
| Binding Sites: | MA1579.2.17 / MA1579.2.7 MA1579.2.1 / MA1579.2.11 / MA1579.2.12 / MA1579.2.2 / MA1579.2.3 / MA1579.2.4 MA1579.1.1 MA1579.1.10 MA1579.1.11 MA1579.1.12 MA1579.1.13 / MA1579.1.7 MA1579.1.14 / MA1579.1.8 MA1579.1.15 / MA1579.1.9 MA1579.1.10 / MA1579.1.16 MA1579.1.11 / MA1579.1.17 MA1579.1.18 MA1579.1.12 / MA1579.1.19 MA1579.1.2 MA1579.1.14 / MA1579.1.20 MA1579.1.1 / MA1579.1.3 MA1579.1.2 / MA1579.1.4 MA1579.1.5 MA1579.1.3 / MA1579.1.6 MA1579.1.4 / MA1579.1.7 MA1579.1.5 / MA1579.1.8 MA1579.1.6 / MA1579.1.9 MA1579.1.13 MA1579.1.15 MA1579.1.16 MA1579.1.17 MA1579.1.18 MA1579.1.19 MA1579.1.20 MA1579.2.10 / MA1579.2.15 / MA1579.2.18 / MA1579.2.5 / MA1579.2.9 MA1579.2.19 MA1579.2.13 MA1579.2.14 MA1579.2.16 MA1579.2.20 MA1579.2.6 MA1579.2.8 |
| Publications: | Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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