Transcription Factor

						

			
Accessions: 2o61_A (3D-footprint 20231221)

			
Names: IRF-3, IRF3_HUMAN, Transcription factor p65/Interferon regulatory factor 7/Interferon regulatory factor 3 fusion protein
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 498
Pfam Domains:     3-168 Rel homology domain (RHD)
  277-388 Interferon regulatory factor transcription factor
  397-497 Interferon regulatory factor transcription factor
Sequence: 
(in bold interface residues)		   1 GYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVT   60
  61 KDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNN  120
 121 NPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICR  180
 181 VNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYA  240
 241 DPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDAAPRVLFGEWLLGEISSGCYEGLQWLD  300
 301 EARTCFRVPWKHFARKDLSEADARIFKAWAVARGRWPPSSRPPPEAETAERAGWKTNFRC  360
 361 ALRSTRRFVMLRDNSGDPADQHKVYALSGSLSSDSLPWLVSQLDLGQLEGVAWVNKSRTR  420
 421 FRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLA  480
 481 EDRSKDPHDPHKIYEFVN
Interface Residues: 15, 17, 18, 20, 21, 23, 24, 25, 117, 169, 171, 200, 228, 345, 346, 354, 355, 356, 357, 359, 360, 363, 364, 375, 427, 429, 461, 465, 466, 468, 469, 472, 473
3D-footprint Homologues: 1a66_A, 1nfk_A, 2ram_A, 1gji_A, 2o61_A, 1a3q_A, 7cli_B, 1imh_C, 4p9u_F, 2pi0_B, 1if1_B, 2irf_L, 7oot_B
Binding Motifs: 2o61_A GGAGAnnTTAAnnnnnnnnnTTCCTC
2o61_AB GGAGAnnTTAAnnTGGGAAnTTCCTC
Binding Sites: 2o61_E
2o61_F
			
Publications: Panne D, Maniatis T, Harrison S.C. An atomic model of the interferon-beta enhanceosome. Cell 129:1111-23 (2007). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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