Transcription Factor

						

			
Accessions: 2pe5_B (3D-footprint 20231221)

			
Names: LACI_ECOLI, Lactose operon repressor
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P03023
Length: 330
Pfam Domains:      4-49 Bacterial regulatory proteins, lacI family
   77-325 Periplasmic binding proteins and sugar binding domain of LacI family
   77-310 Periplasmic binding protein domain
  170-328 Periplasmic binding protein-like domain
Sequence: 
(in bold interface residues)		   1 KPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNRVAQQLAGKQL   60
  61 LLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKAAVHNLLAQRVSG  120
 121 LIINYPLDDQDAIAVEAACTNVPALFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQ  180
 181 IALLAGPLSSVSARLRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTA  240
 241 MLVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSV  300
 301 DRLLQLSQGQAVKGNQLLPVSLVKRKTTLA
Interface Residues: 5, 6, 15, 16, 17, 18, 20, 21, 27, 28, 29, 52, 55, 56, 63
3D-footprint Homologues: 1efa_B, 7ce1_D, 3oqm_C, 1l1m_B, 5ui5_I, 4i2o_B, 1zvv_A, 1jft_A, 1owf_B
Binding Motifs: 2pe5_AB GTGAGCGctCACA
2pe5_B CGCTCACAA
Binding Sites: 2pe5_D
2pe5_E
			
Publications: Daber R, Stayrook S, Rosenberg A, Lewis M. Structural analysis of lac repressor bound to allosteric effectors. Journal of molecular biology 370:609-19 (2007). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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