Transcription Factor

Accessions: 4r2p_A (3D-footprint 20231221)
Names: Wilms tumor protein, isoform 4/CRA_a, WT1_HUMAN, WT33
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P19544
Length: 89
Pfam Domains: 5-29 C2H2-type zinc finger
5-29 Zinc finger, C2H2 type
22-46 Zinc-finger double domain
35-55 Zinc-finger of C2H2 type
35-57 C2H2-type zinc finger
35-57 Zinc finger, C2H2 type
49-75 Zinc-finger double domain
63-85 C2H2-type zinc finger
63-87 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 SEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGE 60
61 KPFSCRWPSCQKKFARSDELVRHHNMHQR
Interface Residues: 17, 18, 19, 20, 21, 23, 24, 25, 45, 46, 47, 48, 49, 50, 51, 52, 53, 71, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82
3D-footprint Homologues: 6jnm_A, 8cuc_F, 1tf3_A, 7y3l_A, 6ml4_A, 7n5w_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 2i13_A, 5kl3_A, 2wbs_A, 1ubd_C, 7ysf_A, 5ei9_F, 2jpa_A, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 2drp_D, 1f2i_J, 7eyi_G, 5k5i_A, 2kmk_A, 8ssu_A, 2gli_A, 1g2f_F, 6blw_A, 8h9h_G, 5v3j_F, 4m9v_C, 2lt7_A, 7y3m_I, 6e94_A, 6wmi_A, 6a57_A, 8gn3_A, 3uk3_C, 5yel_A, 1llm_D, 7txc_E, 5yj3_D
Binding Motifs: 4r2p_A gCGTGGGGt
Binding Sites: 4r2p_B
4r2p_C
Publications: Hashimoto H, Olanrewaju Y.O, Zheng Y, Wilson G.G, Zhang X, Cheng X. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes & development 28:2304-13 (2014). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.