Transcription Factor
| Accessions: | THRB_DBD (HumanTF 1.0), THRB (HT-SELEX2 May2017) |
| Names: | c-erbA-2, c-erbA-beta, Nuclear receptor subfamily 1 group A member 2, THB_HUMAN, THRB, Thyroid hormone receptor beta, ENSG00000151090 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P10828 |
| Notes: | Ensembl ID: ENSG00000151090; DNA-binding domain sequence; TF family: Nuclear_Receptor; Clone source: Gene synthesis, TF family: Nuclear_receptor experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Nuclear_receptor experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Nuclear_receptor experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: Nuclear_receptor experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 115 |
| Pfam Domains: | 21-90 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 QSPSYSQKKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSC 60 61 KYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRR |
| Interface Residues: | 30, 31, 33, 34, 40, 41, 43, 44, 47, 48, 74, 98, 100, 103 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_A, 1hcq_E, 8cef_H, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 8hbm_B, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 7xvn_C, 4iqr_B, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 8rm6_A, 5emc_A |
| Binding Motifs: | THRB_DBD_1 kTGACCTbATrAGGTCAy THRB_DBD_2 kTGACCTyAkTrAGGTCAc THRB_DBD_3 kTGACCTyAywTrAGGwCAc THRB_3 rrGGTCAAAGGTCRb THRB_4 arrGGTCrTGACCyyt THRB_7 gTGwCCTyrhyrAGGwCAc THRB_8 rTGACCTyacrTGACCTyA THRB_methyl_1 grGGTcRaRGGTyrk THRB_methyl_2 arrGGTCrTGACCyyk THRB_methyl_5 gTGwCCTyrwyrAGGwCAc THRB_methyl_6 rTGWCCTyRCrTGWCCTyR |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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