Transcription Factor
| Accessions: | NKX28_MOUSE (HOCOMOCO 10), O70584 (JASPAR 2024) |
| Names: | Homeobox protein NK-2 homolog H, Homeobox protein Nkx-2.8, Homeobox protein Nkx-2.9, NKX28_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O70584 |
| Length: | 235 |
| Pfam Domains: | 82-138 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MATSGRLGFTVRSLLNLPEQDAKPRVRREQQTCVPQTAAWLESECSHYLSSDESGLETSP 60 61 ADSSQLASLRRESPGSDPEKRRKRRVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRL 120 121 TPTQVKIWFQNHRYKLKRGRAPGITEPSDMAASSDLHAAPGLLRRVVVPVLVHDRPPSNN 180 181 GRGEGTSAVPQDKCSARLATACPVPGYTAFGPGSALGLFPAYQHLAPPALVSWNW |
| Interface Residues: | 63, 81, 82, 83, 84, 85, 123, 124, 126, 127, 130, 131, 133, 134, 135, 138, 139, 140 |
| 3D-footprint Homologues: | 5zfz_A, 4j19_B, 6a8r_A, 3cmy_A, 1puf_A, 3d1n_M, 1fjl_B, 8ejp_B, 8pmf_A, 1ig7_A, 1nk2_P, 1zq3_P, 2lkx_A, 7q3o_C, 6es3_K, 1puf_B, 2ld5_A, 8eml_B, 2hdd_A, 9b8u_A, 1jgg_B, 5jlw_D, 4cyc_A, 2r5y_A, 4xrs_G, 2hos_A, 1au7_A, 8osb_E, 6m3d_C, 5flv_I, 3lnq_A, 1b72_A, 5zjt_E, 3a01_E, 7psx_B, 3rkq_B, 8ik5_C, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 1o4x_A, 1du0_A, 4xrm_B, 4qtr_D, 5hod_A |
| Binding Motifs: | NKX28_MOUSE.H10MO.C|M01247 tTCAAGkrc PH0116.1 wttwrAGTACTyrAaty |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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