Transcription Factor
| Accessions: | Q01826 (JASPAR 2024) |
| Names: | DNA-binding protein SATB1, SATB1_HUMAN, Special AT-rich sequence-binding protein 1 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 763 |
| Pfam Domains: | 364-448 CUT domain 487-570 CUT domain 646-701 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHS 60 61 GHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGY 120 121 SHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLP 180 181 PEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWY 240 241 KHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPL 300 301 PNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKP 360 361 LEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQ 420 421 SLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIA 480 481 TERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSP 540 541 ENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQ 600 601 QQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQ 660 661 SFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYK 720 721 EEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD |
| Interface Residues: | 401, 402, 404, 406, 407, 441, 646, 647, 648, 691, 694, 695 |
| 3D-footprint Homologues: | 2d5v_B, 2o4a_A, 1jgg_B |
| Binding Motifs: | MA1963.1 wwwCTAATAAhww MA1963.2 CTAATAA |
| Binding Sites: | MA1963.1.1 MA1963.1.10 / MA1963.1.9 MA1963.1.11 MA1963.1.12 MA1963.1.13 MA1963.1.14 MA1963.1.15 MA1963.1.14 / MA1963.1.16 MA1963.1.15 / MA1963.1.17 MA1963.1.16 / MA1963.1.18 MA1963.1.17 / MA1963.1.19 MA1963.1.2 MA1963.1.18 / MA1963.1.20 MA1963.1.3 MA1963.1.4 MA1963.1.5 MA1963.1.6 MA1963.1.7 MA1963.1.8 MA1963.2.15 MA1963.1.10 MA1963.1.19 MA1963.1.20 MA1963.1.9 MA1963.2.1 / MA1963.2.11 / MA1963.2.12 / MA1963.2.17 / MA1963.2.18 / MA1963.2.19 / MA1963.2.2 / MA1963.2.20 / MA1963.2.4 / MA1963.2.5 / MA1963.2.6 / MA1963.2.7 / MA1963.2.8 MA1963.2.10 / MA1963.2.9 MA1963.2.13 MA1963.2.14 MA1963.2.16 MA1963.2.3 |
| Publications: | Purbey P. K., Singh S., Kumar P. P., Mehta S., Ganesh K. N., Mitra D., Galande S. PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1.. Nucleic Acids Res. 36:2107-2122 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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