Transcription Factor

Accessions: 3uk3_C (3D-footprint 20231221), 4f2j_C (3D-footprint 20231221), 4is1_C (3D-footprint 20231221)
Names: Zinc finger protein 217, ZN217_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: O75362
Length: 52
Pfam Domains: 2-23 Zinc finger, C2H2 type
2-23 C2H2-type zinc finger
16-39 Zinc-finger double domain
29-52 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 RECSYCGKFFRSNYYLNIHLRTHTGEKPYKCEFCEYAAAQKTSLRYHLERHH
Interface Residues: 9, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 24, 26, 39, 40, 41, 42, 43, 44, 45, 46, 47, 50
3D-footprint Homologues: 8gn3_A, 3uk3_C, 7ysf_A, 2kmk_A, 1tf3_A, 6jnm_A, 8cuc_F, 7y3l_A, 7n5w_A, 5ei9_F, 7txc_E, 1mey_C, 6e94_A, 5kl3_A, 6wmi_A, 1f2i_J, 5k5i_A, 5und_A, 2gli_A, 1g2f_F, 5k5l_F, 2lt7_A, 1tf6_A, 6ml4_A, 5v3j_F, 4x9j_A, 1llm_D, 6blw_A, 5kkq_D, 8ssu_A, 1ubd_C, 6u9q_A, 8h9h_G, 4m9v_C, 7eyi_G, 7w1m_H, 8ssq_A, 8gh6_A, 2i13_A, 7y3m_I, 6a57_A, 2jpa_A, 1yuj_A, 5yj3_D, 2wbs_A, 5yel_A
Binding Motifs: 4f2j_C TGcaG
3uk3_C TTCTGCA
3uk3_CD TGCAGAATnnATTCTGCA
4is1_CD TGCAGAATnnATTCTGCA
Binding Sites: 3uk3_A / 3uk3_B
4f2j_A
Publications: Vandevenne M, Jacques D.A, Artuz C, Nguyen C.D, Kwan A.H, Segal D.J, Matthews J.M, Crossley M, Guss J.M, Mackay J.P. New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. The Journal of biological chemistry 288:10616-27 (2013). [Pubmed]
Related annotations: PaperBLAST

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