Transcription Factor

						

			
Accessions: 4egy_B (3D-footprint 20231221), 4h0e_A (3D-footprint 20231221), 5d4s_A (3D-footprint 20231221)

			
Names: Arabinose metabolism transcriptional repressor, ARAR_BACSU
Organisms: Bacillus subtilis, strain 168
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P96711
Length: 70
Pfam Domains:      6-69 Bacterial regulatory proteins, gntR family
    33-67 DeoR-like helix-turn-helix domain
    33-64 HTH domain
Sequence: 
(in bold interface residues)		   1 EFMLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTIRKAIGDLVSQGLLY   60
  61 SVQGGGTFVA
Interface Residues: 7, 31, 32, 33, 36, 42, 43, 44, 45, 46, 47, 48, 63, 64
3D-footprint Homologues: 7zla_B, 6wg7_G, 4wwc_B, 4h0e_A, 4p9u_F, 4u0y_B, 1h9t_B, 6za3_B
Binding Motifs: 4egy_AB TGyACGAaCA
4egy_B TCgnaCA
4h0e_A TGwnyG
4h0e_AB TGtaCGGaCA
5d4s_A CGTATGT
5d4s_AB CrtACGnaCA
Binding Sites: 4egy_T
4egy_U
4h0e_T
4h0e_U
5d4s_T
5d4s_U
			
Publications: Jain D, Nair D.T. Spacing between core recognition motifs determines relative orientation of AraR monomers on bipartite operators. Nucleic acids research 41:639-47 (2013). [Pubmed]


Jain D, Narayanan N, Nair DT. Plasticity in Repressor-DNA Interactions Neutralizes Loss of Symmetry in Bipartite Operators. J Biol Chem 291:1235-42 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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