Transcription Factor

						

			
Accessions: IRF4_full (HumanTF 1.0)

			
Names: Interferon regulatory factor 4, IRF-4, IRF4, IRF4_HUMAN, LSIRF, Lymphocyte-specific interferon regulatory factor, Multiple myeloma oncogene 1, NF-EM5
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q15306
Notes: Ensembl ID: ENSG00000137265; Full protein sequence; TF family: IRF; Clone source: hORFeome
Length: 452
Pfam Domains:    23-129 Interferon regulatory factor transcription factor
  249-417 Interferon-regulatory factor 3
Sequence: 
(in bold interface residues)		   1 MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQ   60
  61 DYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISD  120
 121 PYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRD  180
 181 YVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIR  240
 241 SAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQ  300
 301 RKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFD  360
 361 TQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQN  420
 421 SGHFLRGYDLPEHISNPEDYHRSIRHSSIQE*
Interface Residues: 56, 58, 91, 95, 96, 98, 99, 102, 103
3D-footprint Homologues: 2pi0_B, 1if1_B, 2o61_A, 2irf_L, 7oot_B
Binding Motifs: IRF4_full yCGAAACCGAAACya
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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