Transcription Factor

Accessions: 2hzv_A (3D-footprint 20231221), 2hzv_B (3D-footprint 20231221), 2hzv_C (3D-footprint 20231221), 2hzv_D (3D-footprint 20231221), 2hzv_E (3D-footprint 20231221), 2hzv_F (3D-footprint 20231221), 2hzv_G (3D-footprint 20231221), 2hzv_H (3D-footprint 20231221)
Names: Nickel-responsive regulator, NIKR_ECOLI
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0A6Z6
Length: 131
Pfam Domains: 3-41 Ribbon-helix-helix protein, copG family
54-130 NikR C terminal nickel binding domain
Sequence:
(in bold interface residues)
1 MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVY 60
61 EHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRG 120
121 VRHGHLQCLPK
Interface Residues: 3, 5, 7, 10, 32, 53, 56, 65
3D-footprint Homologues: 1b01_B, 6mrj_D, 2hzv_A, 7nyw_J, 3gxq_A, 5xvp_B
Binding Motifs: 2hzv_A TCAta
2hzv_ABCD GTyTGAnnnnnnnnnnnnnnnnTCAwAC
2hzv_EFGH aGTATGAcnnnnnnnnnnnnnnnTCATAC
Binding Sites: 2hzv_I / 2hzv_K
2hzv_J / 2hzv_L
Publications: Schreiter E.R, Wang S.C, Zamble D.B, Drennan C.L. NikR-operator complex structure and the mechanism of repressor activation by metal ions. Proceedings of the National Academy of Sciences of the United States of America 103:13676-81 (2006). [Pubmed]
Related annotations: PaperBLAST

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