Transcription Factor
| Accessions: | PRRX2_HUMAN (HOCOMOCO 10), Q99811 (JASPAR 2024) |
| Names: | Paired mesoderm homeobox protein 2, Paired-related homeobox protein 2, PRRX2_HUMAN, PRX-2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q99811 |
| Length: | 253 |
| Pfam Domains: | 105-161 Homeobox domain 227-245 OAR domain |
| Sequence: (in bold interface residues) | 1 MDSAAAAFALDKPALGPGPPPPPPALGPGDCAQARKNFSVSHLLDLEEVAAAGRLAARPG 60 61 ARAEAREGAAREPSGGSSGSEAAPQDGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALE 120 121 RVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQ 180 181 EAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGSSGPATPGVNMANSIASLRLKAK 240 241 EFSLHHSQVPTVN |
| Interface Residues: | 105, 106, 107, 108, 146, 147, 149, 150, 153, 154, 157, 158, 161 |
| 3D-footprint Homologues: | 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 6m3d_C, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 5hod_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 4qtr_D, 1o4x_A, 8g87_X, 1du0_A |
| Binding Motifs: | MA0075.3 cyAATTAr PRRX2_HUMAN.H10MO.C|M01469 yTAATTr MA0075.4 cyAATTA |
| Publications: | de Jong R., van der Heijden J., Meijlink F. DNA-binding specificity of the S8 homeodomain. Nucleic Acids Res. 21:4711-4720 (1993). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.