Transcription Factor
| Accessions: | NFIL3_HUMAN (HOCOMOCO 10), Q16649 (JASPAR 2024) |
| Names: | E4 promoter-binding protein 4, Interleukin-3 promoter transcriptional activator, Interleukin-3-binding protein 1, NFIL3_HUMAN, Nuclear factor interleukin-3-regulated protein, Transcriptional activator NF-IL3A |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 462 |
| Pfam Domains: | 72-123 Basic region leucine zipper 79-123 bZIP transcription factor 130-462 Vertebrate interleukin-3 regulated transcription factor |
| Sequence: (in bold interface residues) | 1 MQLRKMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTTGEELLLSEGSVGKNKSSAC 60 61 RRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELL 120 121 SLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKSNVSSFVDEHEPSMVSSSCISVIK 180 181 HSPQSSLSDVSEVSSVEHTQESSVQGSCRSPENKFQIIKQEPMELESYTREPRDDRGSYT 240 241 ASIYQNYMGNSFSGYSHSPPLLQVNRSSSNSPRTSETDDGVVGKSSDGEDEQQVPKGPIH 300 301 SPVELKHVHATVVKVPEVNSSALPHKLRIKAKAMQIKVEAFDNEFEATQKLSSPIDMTSK 360 361 RHFELEKHSAPSMVHSSLTPFSVQVTNIQDWSLKSEHWHQKELSGKTQNSFKTGVVEMKD 420 421 SGYKVSDPENLYLKQGIANLSAEVVSLKRLIATQPISASDSG |
| Interface Residues: | 80, 83, 84, 86, 87, 90, 91, 260, 263, 277 |
| 3D-footprint Homologues: | 6mg1_B, 1dh3_C, 7qw5_A |
| Binding Motifs: | NFIL3_HUMAN.H10MO.C|M01365 rTTAyGTAAykymk MA0025.1 TTAyGTAAyrt MA0025.2 wrTTATGyAAtaw MA0025.3 TTATGyAAt |
| Binding Sites: | MA0025.1.1 MA0025.1.10 MA0025.1.11 MA0025.1.12 MA0025.1.13 MA0025.1.14 MA0025.1.15 MA0025.1.16 MA0025.1.17 MA0025.1.18 MA0025.1.19 MA0025.1.2 MA0025.1.20 MA0025.1.3 MA0025.1.4 MA0025.1.5 MA0025.1.6 MA0025.1.7 MA0025.1.8 MA0025.1.9 MA0025.2.1 MA0025.2.10 MA0025.2.11 / MA0025.2.4 MA0025.2.12 / MA0025.2.5 MA0025.2.13 MA0025.2.14 / MA0025.2.6 MA0025.2.15 / MA0025.2.7 MA0025.2.16 / MA0025.2.8 MA0025.2.17 MA0025.2.18 / MA0025.2.9 MA0025.2.19 MA0025.2.1 / MA0025.2.2 MA0025.2.10 / MA0025.2.20 MA0025.2.3 MA0025.2.4 MA0025.2.5 MA0025.2.6 MA0025.2.2 / MA0025.2.7 MA0025.2.3 / MA0025.2.8 MA0025.2.9 MA0025.2.11 MA0025.2.12 MA0025.2.13 MA0025.2.14 MA0025.2.15 MA0025.2.16 MA0025.2.17 MA0025.2.18 MA0025.2.19 MA0025.2.20 MA0025.3.1 MA0025.3.10 MA0025.3.11 / MA0025.3.15 MA0025.3.12 MA0025.3.13 MA0025.3.14 MA0025.3.16 / MA0025.3.19 / MA0025.3.4 MA0025.3.17 MA0025.3.18 MA0025.3.2 MA0025.3.20 / MA0025.3.5 / MA0025.3.7 / MA0025.3.8 MA0025.3.3 MA0025.3.6 MA0025.3.9 |
| Publications: | Cowell I. G., Skinner A., Hurst H. C. Transcriptional repression by a novel member of the bZIP family of transcription factors. Mol. Cell. Biol. 12:3070-3077 (1992). [Pubmed] Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT. Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. Proc Natl Acad Sci U S A 94:2609-14 (1997). [Pubmed] |
| Related annotations: | PaperBLAST |
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