Transcription Factor
| Accessions: | NHLH1 (HT-SELEX2 May2017) |
| Names: | ENSG00000171786, NHLH1 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: bHLH experiment: HT-SELEX Hamming distance: 2 cycle: 3, TF family: bHLH experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 3, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 86 |
| Pfam Domains: | 30-80 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 PEPGEPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPP 60 61 DKKLSKIEILRLAICYISYLNHVLDV |
| Interface Residues: | 30, 33, 34, 36, 37, 38, 40, 41, 44, 47, 48, 51 |
| 3D-footprint Homologues: | 7z5k_B, 4h10_A, 4h10_B, 8osl_O, 1am9_A, 6od3_F, 8osl_P, 2ypa_B, 2ql2_A, 2ypa_A, 2ql2_D, 5d8c_A |
| Binding Motifs: | NHLH1_2 ggGsmgCAGCTGCGyCmc NHLH1_4 kgGsmgCAGCTGCGyCcc NHLH1_methyl_1 ggGbmkCAGCTGCGyCCc NHLH1_methyl_3 ggGbmgCAGCTGCGyCCc |
| Related annotations: | PaperBLAST |
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