Transcription Factor
| Accessions: | CLOCK_DBD (HumanTF 1.0), CLOCK_TF1 (HumanTF2 1.0), CLOCK_TF2 (HumanTF2 1.0), CLOCK (HT-SELEX2 May2017) |
| Names: | Circadian clock protein PERIOD 1, Circadian pacemaker protein Rigui, CLOCK, hPER1, PER1_HUMAN, Period circadian protein homolog 1, ENSG00000134852 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O15534 |
| Notes: | Ensembl ID: ENSG00000134852; DNA-binding domain sequence; TF family: bHLH; Clone source: Gene synthesis, Ensembl ID: ENSG00000134852; Construct type: TF1(SBP); TF family: bHLH; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000134852; Construct type: TF2(3xFLAG); TF family: bHLH; Clone source: Jolma et al. 2013, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 125 |
| Pfam Domains: | 26-74 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMD 60 61 KSTVLQKSIDFLRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDG 120 121 SIIYV |
| Interface Residues: | 21, 25, 26, 27, 29, 30, 31, 32, 33, 34, 37, 38, 61 |
| 3D-footprint Homologues: | 4zpr_B, 4zpk_B, 1a0a_B, 7ssa_L, 5nj8_D, 4h10_A, 8osl_O, 6g1l_A, 1am9_A, 7xhv_B, 4h10_B, 7d8t_A, 5eyo_A, 7xi3_A, 5v0l_A, 4zpk_A, 7f2f_B, 7xi3_B, 8osl_P, 2ql2_A, 2ypa_B, 5sy7_B, 5nj8_C, 5v0l_B |
| Binding Motifs: | CLOCK_DBD aACACGTGty CLOCK_BHLHA15 wCAYGTGkcyarCAyrTGs CLOCK_EVX1_1 rTaATyayygmCACGTG CLOCK_EVX1_2 CACGTGysGTAATgAT CLOCK_EVX1_2_3 trATwAtyrmcrMACGTG CLOCK_EVX1_2_3_4 yrATwAttsmkkaCAyGTG CLOCK_FIGLA_1 sCAssTGkyvbywaraCRCRTGy CLOCK_FIGLA_2 cCAssTGkygymmsrdrCACGTGs CLOCK_NHLH1_1 cgCAGsTGckmcvrCACGTGbm CLOCK_NHLH1_2 mgCAgcTGyscmvCACGTGbm CLOCK_TBX3 sGTGTgrdysgCACGTG ERF_CLOCK CACGTGkyyGrsmGGAArym ETV2_CLOCK rmCACGTGbcayacCGGAwry ETV5_CLOCK rCACGTGkdggrsCGGAwgy TEAD4_CLOCK_1 rCAcRTGybmcarcATwCy TEAD4_CLOCK_2 vCACGTGymmyycrCATwCC TEAD4_CLOCK_2_3 GGwATGygkskvCACGTGk TEAD4_CLOCK_2_3_4 GGwATGykrskkrCACGTGb CLOCK_2 rmCACGTGyc CLOCK_methyl_1 rmCAyGyGyh |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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