Transcription Factor
| Accessions: | NFATC1 (HT-SELEX2 May2017) |
| Names: | ENSG00000131196, NFATC1 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: RHD_IPT experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: RHD_IPT experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 337 |
| Pfam Domains: | 38-198 Rel homology domain (RHD) 212-303 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 QHPYQWAKPKPLSPTSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGA 60 61 VKASAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAI 120 121 LSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQ 180 181 PSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFV 240 241 EKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHVSFYVCNGKRKRSQYQR 300 301 FTYLPANVPIIKTEPTDDYEPAPTCGPVSQGLSPLPR |
| Interface Residues: | 49, 51, 52, 54, 55, 58, 148, 165, 198, 199, 200, 229, 292, 293 |
| 3D-footprint Homologues: | 2o61_A, 1a66_A, 9bdw_A, 1imh_C, 1p7h_L |
| Binding Motifs: | NFATC1_3 kTTTCCrytaayGGAAAm NFATC1_4 kTTTCCATGGAAAm NFATC1_methyl_1 tTTTCCrytaryGGAAAa NFATC1_methyl_2 tTTTCCRYGGAAAa |
| Related annotations: | PaperBLAST |
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