Transcription Factor
| Accessions: | ETV4_DBD (HumanTF 1.0), ETV4_TF2 (HumanTF2 1.0) |
| Names: | Adenovirus E1A enhancer-binding protein, E1A-F, ETS translocation variant 4, ETV4, ETV4_HUMAN, Polyomavirus enhancer activator 3 homolog, Protein PEA3 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P43268 |
| Notes: | Ensembl ID: ENSG00000175832; DNA-binding domain sequence; TF family: ETS; Clone source: MGC, Ensembl ID: ENSG00000175832; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013 |
| Length: | 134 |
| Pfam Domains: | 26-107 Ets-domain |
| Sequence: (in bold interface residues) | 1 MAEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPE 60 61 EVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDN 120 121 QRPALKAEFDRPVS |
| Interface Residues: | 78, 79, 81, 82, 83, 85, 86, 100 |
| 3D-footprint Homologues: | 8ee9_F, 4uno_A, 3jtg_A, 1dux_F, 3zp5_A, 7jsa_J, 4mhg_A, 2stt_A, 4iri_A, 1bc8_C, 4l18_B, 5d5w_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A |
| Binding Motifs: | ETV4_DBD aCCGGAwrtr FOXO1_ETV4_1 rccGGAwGTkkw FOXO1_ETV4_2 rwmAACAGGAwGyr GCM1_ETV4 aTrCGGGCGGAAGyr HOXB2_ETV4 rCCGGAAATgrs HOXD12_ETV4_1 rCCGGAAGTaATAAAm HOXD12_ETV4_2 aCCGGAAGTCGTWAAm POU2F1_ETV4_1 / POU2F1_ETV4_2 ACCGgATATGCAd TEAD4_ETV4 ACCGGAAATrcC TFAP4_ETV4 rsCGGAwvCAgsTGkb |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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