Transcription Factor

Accessions: ETV4_DBD (HumanTF 1.0), ETV4_TF2 (HumanTF2 1.0)
Names: Adenovirus E1A enhancer-binding protein, E1A-F, ETS translocation variant 4, ETV4, ETV4_HUMAN, Polyomavirus enhancer activator 3 homolog, Protein PEA3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P43268
Notes: Ensembl ID: ENSG00000175832; DNA-binding domain sequence; TF family: ETS; Clone source: MGC, Ensembl ID: ENSG00000175832; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013
Length: 134
Pfam Domains: 26-107 Ets-domain
Sequence:
(in bold interface residues)
1 MAEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPE 60
61 EVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDN 120
121 QRPALKAEFDRPVS
Interface Residues: 78, 79, 81, 82, 83, 85, 86, 100
3D-footprint Homologues: 8ee9_F, 4uno_A, 3jtg_A, 1dux_F, 3zp5_A, 7jsa_J, 4mhg_A, 2stt_A, 4iri_A, 1bc8_C, 4l18_B, 5d5w_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A
Binding Motifs: ETV4_DBD aCCGGAwrtr
FOXO1_ETV4_1 rccGGAwGTkkw
FOXO1_ETV4_2 rwmAACAGGAwGyr
GCM1_ETV4 aTrCGGGCGGAAGyr
HOXB2_ETV4 rCCGGAAATgrs
HOXD12_ETV4_1 rCCGGAAGTaATAAAm
HOXD12_ETV4_2 aCCGGAAGTCGTWAAm
POU2F1_ETV4_1 / POU2F1_ETV4_2 ACCGgATATGCAd
TEAD4_ETV4 ACCGGAAATrcC
TFAP4_ETV4 rsCGGAwvCAgsTGkb
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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