Transcription Factor
| Accessions: | 1o3s_A (3D-footprint 20231221) |
| Names: | cAMP receptor protein, cAMP regulatory protein, cAMP-activated global transcriptional regulator CRP, CAP, Catabolite activator protein, CATABOLITE GENE ACTIVATOR PROTEIN, CRP_ECOLI |
| Organisms: | Escherichia coli, strain K12 |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P0ACJ8 |
| Length: | 200 |
| Pfam Domains: | 15-103 Cyclic nucleotide-binding domain 134-198 Crp-like helix-turn-helix domain 158-189 Bacterial regulatory proteins, crp family |
| Sequence: (in bold interface residues) | 1 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQG 60 61 DFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVT 120 121 SEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRDTVGRIL 180 181 KMLEDQNLISAHGKTIVVYG |
| Interface Residues: | 19, 73, 158, 163, 172, 173, 174, 175, 177, 178 |
| 3D-footprint Homologues: | 3iyd_H, 4a12_B, 2xro_E, 3e6c_C, 4i2o_B, 5i2d_R, 3mzh_A, 7pza_B |
| Binding Motifs: | 1o3s_A TCgc |
| Binding Sites: | 1o3s_B 1o3s_C |
| Publications: | Chen S., Gunasekera A., Zhang X., Kunkel TA., Ebright RH., Berman HM. Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: alteration of DNA binding specificity through alteration of DNA kinking. J Mol Biol. 314(1):75-82 (2001). [Pubmed] |
| Related annotations: | PaperBLAST |
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