Transcription Factor

						

			
Accessions: 6dfa_A (3D-footprint 20231221)

			
Names: KAISO_HUMAN, Transcriptional regulator Kaiso, Zinc finger and BTB domain-containing protein 33
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q86T24
Length: 120
Pfam Domains:     28-51 Zinc-finger double domain
    42-64 C2H2-type zinc finger
    58-80 Zinc-finger double domain
    70-93 C2H2-type zinc finger
    70-93 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 DDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVFPLAAYRTKH   60
  61 EIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHPCRSLQIRQYAYL  120
Interface Residues: 14, 24, 25, 26, 27, 28, 30, 31, 33, 34, 37, 52, 53, 54, 55, 56, 58, 59, 60, 80, 81, 82, 83, 84, 85, 86, 87, 88, 91, 115, 117
3D-footprint Homologues: 2kmk_A, 6ml4_A, 7n5w_A, 6jnm_A, 1tf3_A, 2gli_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 2i13_A, 6e94_A, 5kl3_A, 1ubd_C, 7ysf_A, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 7eyi_G, 5k5i_A, 8ssu_A, 5v3j_F, 8h9h_G, 2lt7_A, 6a57_A, 2jpa_A, 3uk3_C, 8cuc_F, 7y3l_A, 8gn3_A, 5yel_A, 1llm_D, 7txc_E, 2wbs_A, 2drp_D, 1f2i_J, 4m9v_C, 7y3m_I, 5yj3_D
Binding Motifs: 6dfa_A TGGCAGGA
Binding Sites: 6dfa_D
6dfa_E
			
Publications: Nikolova EN, Stanfield RL, Dyson HJ, Wright PE. A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences. Biochemistry 59:1909-1926 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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