Transcription Factor
| Accessions: | UP00613A (UniPROBE 20160601) |
| Names: | Homeobox protein PBX4, PBX4_REF, pre-B-cell leukemia transcription factor 4 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | pre-B-cell leukemia transcription factor 4: This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provid |
| Length: | 93 |
| Pfam Domains: | 17-76 Homeobox domain 35-73 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 STCEAVMTLRSRLLDARRKRRNFSKQATEVLNEYFYSHLNNPYPSEEAKEELARKGGLTI 60 61 SQVSNWFGNKRIRYKKNMGKFQEEATIYTGKTA |
| Interface Residues: | 1, 17, 18, 19, 20, 21, 61, 62, 64, 65, 68, 69, 72, 73, 76 |
| 3D-footprint Homologues: | 1au7_A, 6a8r_A, 3d1n_M, 5zfz_A, 6fqp_B, 1puf_A, 1fjl_B, 3cmy_A, 1zq3_P, 1jgg_B, 2lkx_A, 2ld5_A, 1puf_B, 1b72_A, 4cyc_A, 5zjt_E, 5hod_A, 3l1p_A, 5jlw_D, 1ig7_A, 4j19_B, 7q3o_C, 1le8_A, 8g87_X, 4xrm_B, 2hdd_A, 1le8_B, 6m3d_C, 2r5y_A, 6es3_K, 4xrs_G, 1mnm_C, 7psx_B, 1du0_A, 3a01_E, 2d5v_B, 1k61_B, 5flv_I, 3lnq_A, 4qtr_D, 2h1k_B, 6fqq_E, 3rkq_B, 2hos_A |
| Binding Motifs: | UP00613A_1 wmaAwawkkTGACATGhmabgwk UP00613A_2 rmmawawwkTGACATGymatsdg |
| Binding Sites: | TGACGTCA ACATCAAT ACATGTCA ATCAATCA ATGACGAG CACATCAA CATCAATC GCTCGTCA TCAATCAA TCATCAAA ACTCGTCA ATGACATG ATTCGTCA CATGTCAA CATGTCAC CGTCAAAA CGTCAAAG CTCGTCAA CTCGTCAC GACATGTC GCATGTCA TCGTCAAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.