Transcription Factor

						

			
Accessions: P23759 (JASPAR 2024)

			
Names: HuP1, Paired box protein Pax-7, PAX7_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P23759
Length: 505
Pfam Domains:    34-161 'Paired box' domain
  218-274 Homeobox domain
  241-271 Homeobox KN domain
  345-385 Paired box protein 7 
Sequence: 
(in bold interface residues)		   1 MAALPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIV   60
  61 EMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPRQVATPDVEKKIEE  120
 121 YKRENPGMFSWEIRDRLLKDGHCDRSTVPSGLVSSISRVLRIKFGKKEEEDEADKKEDDG  180
 181 EKKAKHSIDGILGDKGNRLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTH  240
 241 YPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLAAFNHLLPGGFPPTGMPTL  300
 301 PPYQLPDSTYPTTTISQDGGSTVHRPQPLPPSTMHQGGLAAAAAAADTSSAYGARHSFSS  360
 361 YSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVPPQPQADFSISPLHGGLDSATSIS  420
 421 ASCSQRADSIKPGDSLPTSQAYCPPTYSTTGYSVDPVAGYQYGQYGQTAVDYLAKNVSLS  480
 481 TQRRMKLGEHSAVLGLLPVETGQAY
Interface Residues: 47, 79, 80, 82, 84, 85, 101, 104, 107, 150, 153, 154, 155, 157, 158, 161, 217, 218, 219, 220, 221, 259, 260, 262, 263, 266, 267, 269, 270, 271, 273, 274
3D-footprint Homologues: 1pdn_C, 6pax_A, 1k78_A, 4j19_B, 1ig7_A, 3cmy_A, 6a8r_A, 3d1n_M, 2h1k_B, 1fjl_B, 1puf_A, 5zfz_A, 6fqp_B, 3lnq_A, 1jgg_B, 1zq3_P, 6m3d_C, 2lkx_A, 1nk2_P, 7q3o_C, 2ld5_A, 6es3_K, 5flv_I, 2r5y_A, 1puf_B, 7psx_B, 5zjt_E, 2hos_A, 5hod_A, 3rkq_B, 5jlw_D, 1au7_A, 4cyc_A, 4xrs_G, 3l1p_A, 1b72_A, 3a01_E, 2hdd_A, 1le8_A, 2xsd_C, 1e3o_C, 7xrc_C, 1du0_A, 4qtr_D, 1o4x_A, 6fqq_E, 1le8_B, 4xrm_B, 1k61_B, 1mnm_C, 8g87_X, 2ypa_A
Binding Motifs: MA0680.1 TAATCRATTA
			
Publications: Smith S. B., Ee H. C., Conners  J. R., German M. S. Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Mol. Cell. Biol. 19:8272-8280 (1999). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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