Transcription Factor
| Accessions: | SRBP2_HUMAN (HOCOMOCO 10), Q12772 (JASPAR 2024) |
| Names: | bHLHd2, Class D basic helix-loop-helix protein 2, SRBP2_HUMAN, SREBP-2, Sterol regulatory element-binding protein 2, Sterol regulatory element-binding transcription factor 2, Transcription factor SREBF2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q12772 |
| Length: | 1142 |
| Pfam Domains: | 331-381 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGS 60 61 GSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTS 120 121 VPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQV 180 181 LQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVP 240 241 VLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILT 300 301 TMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGT 360 361 DAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLK 420 421 IEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRS 480 481 RILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLL 540 541 LWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTC 600 601 LAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAK 660 661 TSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTA 720 721 AMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSA 780 781 AKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEY 840 841 LKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFT 900 901 KVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSG 960 961 ATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLG SLR 1020 1021 RLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRE 1080 1081 RATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIA 1140 1141 AS |
| Interface Residues: | 332, 334, 335, 336, 338, 339, 342, 343, 364, 366 |
| 3D-footprint Homologues: | 2ypa_A, 1an4_A, 7ssa_L, 5gnj_I, 6g1l_A, 4h10_B, 7xi3_A, 5i50_B, 1am9_A, 7d8t_A, 4zpk_A, 8osl_O, 5nj8_D, 7f2f_B, 5eyo_A, 5v0l_A |
| Binding Motifs: | MA0828.1 ATCACGTGAy MA0596.1 rTGGgGTGAy MA1933.1 rcCGGAAGTsrCGTGA MA1939.1 ssCGGAArTCACGTGAy SRBP2_HUMAN.H10MO.B|M01534 rsgTGGggwGAkg MA0828.2 wtrTCACGTGAyaw MA0828.3 rTCACGTGAy MA1933.2 cCGGAAGTsrCGTGA MA1939.2 sCGGAArTCACGTGAy |
| Binding Sites: | MA0596.1.1 MA0596.1.10 MA0596.1.11 MA0596.1.12 MA0596.1.13 MA0596.1.14 MA0596.1.15 MA0596.1.16 MA0596.1.17 MA0596.1.18 MA0596.1.19 MA0596.1.2 MA0596.1.20 MA0596.1.3 MA0596.1.4 MA0596.1.5 MA0596.1.6 MA0596.1.7 MA0596.1.8 MA0596.1.9 |
| Publications: | Wang X., Sato R. R., Brown M. S., Hua X., Goldstein J. L. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77:53-62 (1994). [Pubmed] Shimano H. Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40:439-52 (2001). [Pubmed] Chatterjee R, Zhao J, He X, Shlyakhtenko A, Mann I, Waterfall JJ, Meltzer P, Sathyanarayana BK, FitzGerald PC, Vinson C. Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins. G3 (Bethesda) 2:1243-56 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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