Transcription Factor

Accessions: 5i2d_R (3D-footprint 20231221)
Names: CRP/FNR superfamily protein LdrP, Cyclic AMP receptor protein/Fumarate and nitrate reduction regulator superfamily protein LdrP, LDRP_THET8, Light induced transcription regulator-dependent regulatory protein, LitR-dependent regulatory protein, Transcriptional regulator LdrP, Transcriptional regulator, Crp family
Organisms: strain HB8 / ATCC 27634 / DSM 579, Thermus thermophilus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q53W63
Length: 195
Pfam Domains: 2-74 Cyclic nucleotide-binding domain
114-186 Crp-like helix-turn-helix domain
139-169 Bacterial regulatory proteins, crp family
Sequence:
(in bold interface residues)
1 MKRFARKETIYLRGEEARTLYRLEEGLVRVVELLPDGRLITLRHVLPGDYFGEEALEGKA 60
61 YRYTAEAMTEAVVQGLEPRAMDHEALHRVARNLARQMRRVQAYEAHLQTGELRARIARYL 120
121 LFLADTPLSARDRQGIYVTVSHEEIADATASIRESVSKVLADLRREGLIATAYRRVYLLD 180
181 LAALEREAGSALEAA
Interface Residues: 7, 143, 152, 153, 154, 155, 157, 158
3D-footprint Homologues: 3iyd_H, 3mzh_A, 7pza_B, 4i2o_B, 3e6c_C, 5i2d_R, 5lej_A
Binding Motifs: 5i2d_R tCAcA
Binding Sites: 5i2d_T
5i2d_U
Publications: Feng Y, Zhang Y, Ebright RH. Structural basis of transcription activation. Science 352:1330-3 (2016). [Pubmed]
Related annotations: PaperBLAST

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