Transcription Factor
| Accessions: | PRDM1_full (HumanTF 1.0) |
| Names: | A8K0J1_HUMAN, cDNA FLJ76731, highly similar to Homo sapiens PR domain containing 1, with ZNF domain, PRDM1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Uniprot: | A8K0J1 |
| Notes: | Ensembl ID: ENSG00000057657; Full protein sequence; TF family: znfC2H2; Clone source: hORFeome |
| Length: | 826 |
| Pfam Domains: | 100-200 SET domain 575-597 C2H2-type zinc finger 575-597 Zinc finger, C2H2 type 589-613 Zinc-finger double domain 603-625 C2H2-type zinc finger 603-625 Zinc finger, C2H2 type 617-642 Zinc-finger double domain 631-653 Zinc finger, C2H2 type 631-653 C2H2-type zinc finger 645-669 Zinc-finger double domain 659-681 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MLDICLEKRVGTTLAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTY 60 61 IVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEI 120 121 YTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGM 180 181 NIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCP 240 241 KNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYP 300 301 IRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTV 360 361 SPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGM 420 421 NCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQ 480 481 PEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAA 540 541 PSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGE 600 601 RPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQ 660 661 CKVCPAKFTQFVHLKLHKRLHTRERPHKCSQCHKNYIHLCSLKVHLKGNCAAAPAPGLPL 720 721 EDLTRINEEIEKFDISDNADRLEDVEDDISVISVVEKEILAVVRKEKEETGLKVSLQRNM 780 781 GNGLLSSGCSLYESSDLPLMKLPPSNPLPLVPVKVKQETVEPMDP* |
| Interface Residues: | 540, 542, 547, 548, 551, 564, 575, 585, 586, 587, 588, 589, 591, 592, 593, 596, 605, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 626, 628, 641, 642, 643, 644, 645, 647, 648, 651, 670, 671, 672, 673, 675, 676, 698, 699, 700, 701, 702, 703, 704 |
| 3D-footprint Homologues: | 5v3j_F, 2i13_A, 6wmi_A, 7w1m_H, 2kmk_A, 6jnm_A, 8cuc_F, 1tf3_A, 8ssq_A, 1tf6_A, 5k5l_F, 8ssu_A, 8gn3_A, 5kkq_D, 6u9q_A, 5ei9_F, 4m9v_C, 6e94_A, 7ysf_A, 2lt7_A, 7y3m_I, 6a57_A, 5yel_A, 1ubd_C, 2gli_A, 7n5w_A, 5kl3_A, 2drp_D, 1g2f_F, 5und_A, 6ml4_A, 4x9j_A, 1mey_C, 6blw_A, 2wbs_A, 7txc_E, 7eyi_G, 8h9h_G, 2jpa_A, 1yuj_A, 3uk3_C, 7y3l_A, 5k5i_A, 1llm_D, 1f2i_J, 5yj3_D |
| Binding Motifs: | PRDM1_full wrAAAGTGAAAGTgr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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