Transcription Factor
| Accessions: | P70390 (JASPAR 2024) |
| Names: | Homeobox protein Og12X, OG-12, Paired family homeodomain protein Prx3, Short stature homeobox protein 2, SHOX2_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 331 |
| Pfam Domains: | 141-197 Homeobox domain 310-328 OAR domain |
| Sequence: (in bold interface residues) | 1 MEELTAFVSKSFDQKVKEKKEAITYREVLESGPLRGAKEPGCVEPGRDDRSSPAVRAAGG 60 61 GGGAGGGGGGGGGGGGGAGGGGAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEVSPEL 120 121 KDRKDDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLS 180 181 EARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNV 240 241 TPLSFQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMMFPAPPFGLPLATLAADSASAASVV 300 301 AAAAAAKTTSKNSSIADLRLKAKKHAAALGL |
| Interface Residues: | 140, 141, 142, 143, 144, 182, 183, 185, 186, 189, 190, 193, 194, 197 |
| 3D-footprint Homologues: | 4j19_B, 5zfz_A, 1ig7_A, 6fqp_B, 5zjt_E, 3cmy_A, 2h1k_B, 1puf_A, 6a8r_A, 3d1n_M, 1fjl_B, 1zq3_P, 3lnq_A, 1jgg_B, 6m3d_C, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 1b72_A, 3a01_E, 5flv_I, 5hod_A, 3rkq_B, 2hdd_A, 6wig_A, 1au7_A, 5jlw_D, 4cyc_A, 2r5y_A, 1puf_B, 4xrs_G, 3l1p_A, 2hos_A, 7psx_B, 7xrc_C, 1e3o_C, 1le8_A, 1o4x_A, 1du0_A, 4qtr_D, 4xrm_B, 8g87_X |
| Binding Motifs: | MA0720.1 yyAATTAr PH0160.1 ckmsyTAATTArtyrds MA0720.2 yAATTA |
| Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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