Transcription Factor

						

			
Accessions: CEBPB_HUMAN (HOCOMOCO 10), P17676 (JASPAR 2024)

			
Names: C/EBP beta, CCAAT/enhancer-binding protein beta, CEBPB_HUMAN, LAP, LIP, Liver activator protein, Liver-enriched inhibitory protein, Nuclear factor NF-IL6, TCF-5, Transcription factor 5
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P17676
Length: 345
Pfam Domains:   270-323 Basic region leucine zipper
  271-329 bZIP transcription factor
Sequence: 
(in bold interface residues)		   1 MQRLVAWDPACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGPRPPA   60
  61 GELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPPAPAPAPASSGQHHDFLSD  120
 121 LFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPLHPPPPPPPPPAELKAEPGFE  180
 181 PADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPAD  240
 241 AKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQ  300
 301 HKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC
Interface Residues: 95, 277, 278, 281, 282, 284, 285, 288, 289, 292, 293
3D-footprint Homologues: 3pih_A, 2wt7_A, 6mg1_B, 1nwq_C, 2c9l_Z, 2dgc_A, 5t01_B, 2wt7_B
Binding Motifs: MA0466.2 rTTrCGCAAy
MA0466.1 kATTGCAymAy
CEBPB_HUMAN.H10MO.A|M01049 krTTGCryMAym
MA0466.3 kATTGCGCAATm
MA0466.4 ATTGCGCAAT
Binding Sites: MA0466.1.1
MA0466.1.10
MA0466.1.11
MA0466.1.12
MA0466.1.13
MA0466.1.14
MA0466.1.15
MA0466.1.16
MA0466.1.17
MA0466.1.18
MA0466.1.19
MA0466.1.2
MA0466.1.20
MA0466.1.3
MA0466.1.4
MA0466.1.5
MA0466.1.6
MA0466.1.7
MA0466.1.8
MA0466.1.9
			
Publications: Kyo S, Inoue M, Nishio Y, Nakanishi K, Akira S, Inoue H, Yutsudo M, Tanizawa O, Hakura A. NF-IL6 represses early gene expression of human papillomavirus type 16 through binding to the noncoding region. Journal of virology 67:1058-66 (1993). [Pubmed]


Osada S, Yamamoto H, Nishihara T, Imagawa M. DNA binding specificity of the CCAAT/enhancer-binding protein transcription factor family. J Biol Chem 271:3891-6 (1996). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.