Transcription Factor

						

			
Accessions: GMEB1 (HT-SELEX2 May2017)

			
Names: ENSG00000162419, GMEB1
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: SAND experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: SAND experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 573
Pfam Domains:    88-166 SAND domain
Sequence: 
(in bold interface residues)		   1 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSE   60
  61 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC  120
 121 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS  180
 181 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA  240
 241 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD  300
 301 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS  360
 361 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG  420
 421 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ  480
 481 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV  540
 541 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED
Interface Residues: 337, 375
3D-footprint Homologues: 4h5q_B
Binding Motifs: GMEB1_2 kTACGTAmwkTACGTAm
GMEB1_methyl_1 ktrCGTrrtyaCGyaa
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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