Transcription Factor

						

			
Accessions: Q9UPG8 (JASPAR 2024)

			
Names: PLAL2_HUMAN, Pleiomorphic adenoma-like protein 2, Zinc finger protein PLAGL2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9UPG8
Length: 496
Pfam Domains:     68-92 Zinc finger, C2H2 type
    68-92 C2H2-type zinc finger
   85-108 Zinc-finger double domain
   98-120 C2H2-type zinc finger
   98-120 Zinc finger, C2H2 type
  112-138 Zinc-finger double domain
  128-149 C2H2-type zinc finger
  170-202 Zinc-finger double domain
  191-213 C2H2-type zinc finger
  206-229 Zinc-finger double domain
  219-242 C2H2-type zinc finger
  221-242 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MTTFFTSVPPWIQDAKQEEEVGWKLVPRPRGREAESQVKCQCEISGTPFSNGEKLRPHSL   60
  61 PQPEQRPYSCPQLHCGKAFASKYKLYRHMATHSAQKPHQCMYCDKMFHRKDHLRNHLQTH  120
 121 DPNKEALHCSECGKNYNTKLGYRRHLAMHAASSGDLSCKVCLQTFESTQALLEHLKAHSR  180
 181 RVAGGAKEKKHPCDHCDRRFYTRKDVRRHLVVHTGRKDFLCQYCAQRFGRKDHLTRHVKK  240
 241 SHSQELLKIKTEPVDMLGLLSCSSTVSVKEELSPVLCMASRDVMGTKAFPGMLPMGMYGA  300
 301 HIPTMPSTGVPHSLVHNTLPMGMSYPLESSPISSPAQLPPKYQLGSTSYLPDKLPKVEVD  360
 361 SFLAELPGSLSLSSAEPQPASPQPAAAAALLDEALLAKSPANLSEALCAANVDFSHLLGF  420
 421 LPLNLPPCNPPGATGGLVMGYSQAEAQPLLTTLQAQPQDSPGAGGPLNFGPLHSLPPVFT  480
 481 SGLSSTTLPRFHQAFQ
Interface Residues: 51, 52, 53, 54, 57, 80, 81, 82, 83, 84, 87, 88, 108, 109, 110, 111, 112, 113, 114, 115, 116, 137, 138, 139, 140, 141, 144, 145, 148, 156, 166, 167, 168, 169, 170, 171, 172, 173, 174, 176, 177, 179, 180, 183, 200, 201, 202, 203, 204, 205, 207, 208, 212, 229, 230, 231, 232, 233, 235, 236, 240
3D-footprint Homologues: 2gli_A, 8ssu_A, 5kkq_D, 1ubd_C, 5v3j_F, 8ssq_A, 6u9q_A, 6a57_A, 7w1m_H, 5yel_A, 7y3l_A, 7n5w_A, 3uk3_C, 8cuc_F, 1tf3_A, 1f2i_J, 2wbs_A, 1tf6_A, 5ei9_F, 1g2f_F, 5kl3_A, 5k5i_A, 5k5l_F, 4x9j_A, 8h9h_G, 4m9v_C, 7ysf_A, 6ml4_A, 5yj3_D, 6e94_A, 2kmk_A, 6jnm_A, 2lt7_A, 6blw_A, 2jpa_A, 8gn3_A, 7txc_E, 1llm_D, 2drp_D, 7y3m_I
Binding Motifs: MA1548.1 tGGGCCCCCt
MA1548.2 GGGCCCCC
			
Publications: Mizutani A, Furukawa T, Adachi Y, Ikehara S, Taketani S. A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis. J Biol Chem 277:15851-8 (2002). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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