Transcription Factor

						

			
Accessions: Q15935 (JASPAR 2024)

			
Names: Zinc finger protein 77, ZNF77_HUMAN, ZNFpT1
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q15935
Length: 545
Pfam Domains:      4-44 KRAB box
  212-235 C2H2-type zinc finger
  227-249 Zinc-finger double domain
  239-258 C2H2-type zinc finger
  240-262 Zinc finger, C2H2 type
  240-262 C2H2-type zinc finger
  255-279 Zinc-finger double domain
  267-279 C2H2-type zinc finger
  268-290 C2H2-type zinc finger
  268-290 Zinc finger, C2H2 type
  283-307 Zinc-finger double domain
  295-318 C2H2-type zinc finger
  296-318 C2H2-type zinc finger
  311-335 Zinc-finger double domain
  325-346 C2H2-type zinc finger
  325-346 C2H2-type zinc finger
  338-362 Zinc-finger double domain
  351-374 C2H2-type zinc finger
  352-374 C2H2-type zinc finger
  352-374 Zinc finger, C2H2 type
  366-390 Zinc-finger double domain
  380-402 C2H2-type zinc finger
  380-390 C2H2-type zinc finger
  395-418 Zinc-finger double domain
  408-424 C2H2-type zinc finger
  408-430 C2H2-type zinc finger
  408-430 Zinc finger, C2H2 type
  422-447 Zinc-finger double domain
  435-458 C2H2-type zinc finger
  436-458 C2H2-type zinc finger
  436-458 Zinc finger, C2H2 type
  450-475 Zinc-finger double domain
  463-486 C2H2-type zinc finger
  464-486 C2H2-type zinc finger
  464-486 Zinc finger, C2H2 type
  479-503 Zinc-finger double domain
  491-514 C2H2-type zinc finger
  492-514 C2H2-type zinc finger
  492-514 Zinc finger, C2H2 type
  506-530 Zinc-finger double domain
  519-542 C2H2-type zinc finger
  520-542 C2H2-type zinc finger
  520-542 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MDCVIFEEVAVNFTPEEWALLDHAQRSLYRDVMLETCRNLASLDCYIYVRTSGSSSQRDV   60
  61 FGNGISNDEEIVKFTGSDSWSIFGENWRFDNTGDQHQIPQRHLRSQLGRLCESNEGHQCG  120
 121 ETLSQTANLLVHKSYPTEAKPSECTKCGKAFENRQRSHTGQRPCKECGQACSCLSCQSPP  180
 181 MKTQTVEKPCNCQDSRTASVTYVKSLSSKKSYECQKCGKAFICPSSFRGHVNSHHGQKTH  240
 241 ACKVCGKTFMYYSYLTRHVRTHTGEKPYECKECGKAFSCPSYFREHVRTHTGEKPYECKH  300
 301 CGKSFSCYSSFRDHVRTHTGEKPCQCKHCGKAFTCYSSLREHGRTHSGEKPYECKECGKA  360
 361 FRYPSSLRAHMRMHTGEKPYVCKQCGKAFGCPTYFRRHVKTHSGVKPYQCKECGKAYSFS  420
 421 SSLRIHVRTHTGEKPFECKHCGKAFSCHSSLREHVRTHSGEKPYECNQCGKAFSHAQYFQ  480
 481 KHVRSHSGVKPYECTECGKAYSCSSSLRVHVRTHTGERPYECKQCGKTFRYLASLQAHVR  540
 541 THAGA
Interface Residues: 225, 226, 228, 229, 250, 251, 252, 253, 254, 257, 278, 279, 280, 281, 282, 285, 307, 308, 309, 310, 313, 335, 336, 337, 338, 340, 341, 352, 363, 364, 365, 366, 368, 369, 371, 372, 375, 390, 391, 393, 394, 395, 397, 398, 401, 418, 419, 420, 421, 422, 425, 428, 446, 447, 448, 449, 450, 453, 457, 459, 473, 474, 475, 476, 477, 478, 480, 481, 485, 502, 503, 504, 505, 506, 530, 531, 533, 534, 537
3D-footprint Homologues: 2lt7_A, 7n5w_A, 6u9q_A, 2gli_A, 7w1m_H, 8h9h_G, 8ssq_A, 8ssu_A, 5v3j_F, 2kmk_A, 8gn3_A, 6e94_A, 2jpa_A, 7ysf_A, 8cuc_F, 7y3l_A, 1tf3_A, 1tf6_A, 7y3m_I, 1ubd_C, 2drp_D, 7txc_E
Binding Motifs: UN0655.1 ymyCACTyCACCmys
UN0655.2 myCACTyCACC
Binding Sites: UN0655.1.1
UN0655.1.10
UN0655.1.11 / UN0655.1.12
UN0655.1.12 / UN0655.1.13
UN0655.1.13 / UN0655.1.16
UN0655.1.14 / UN0655.1.18
UN0655.1.15 / UN0655.1.19
UN0655.1.16
UN0655.1.17
UN0655.1.18
UN0655.1.19
UN0655.1.2
UN0655.1.20
UN0655.1.3
UN0655.1.4
UN0655.1.5
UN0655.1.6
UN0655.1.7
UN0655.1.8
UN0655.1.10 / UN0655.1.9
UN0655.1.11
UN0655.1.14
UN0655.1.15
UN0655.1.17
UN0655.1.20
UN0655.1.9
UN0655.2.1 / UN0655.2.11
UN0655.2.10
UN0655.2.12 / UN0655.2.7
UN0655.2.13
UN0655.2.14 / UN0655.2.2
UN0655.2.15
UN0655.2.16
UN0655.2.17
UN0655.2.18 / UN0655.2.8
UN0655.2.19
UN0655.2.20
UN0655.2.3
UN0655.2.4
UN0655.2.5
UN0655.2.6
UN0655.2.9
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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