Transcription Factor
| Accessions: | RORB_TF1 (HumanTF2 1.0), RORB (HT-SELEX2 May2017) |
| Names: | cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB, Q58EY0_HUMAN, RAR-related orphan receptor B, RAR-related orphan receptor beta, RORB, ENSG00000198963 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q58EY0 |
| Notes: | Ensembl ID: ENSG00000198963; Construct type: TF1(SBP); TF family: Nuclear_receptor; Clone source: Megaman, TF family: Nuclear_receptor experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: Nuclear_receptor experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 99 |
| Pfam Domains: | 7-75 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 AQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRC 60 61 QHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQ |
| Interface Residues: | 16, 17, 19, 20, 26, 27, 29, 30, 33, 34, 58, 80, 82 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A |
| Binding Motifs: | RORB_1 AwgTrGGTyAGTRGGTCA RORB_2 AwstRGGTCATGACCYaswT RORB_3 dAwgTrGGTyAGTrGGTCAs RORB_4 wAwstRGGTCRTGACCYaswTw RORB_methyl_1 dAwgTrGGTyAGTRGGTCRc RORB_methyl_2 wAwstRGGTCrTGACCYaswTw |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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