Transcription Factor

						

			
Accessions: 4zpr_B (3D-footprint 20231221)

			
Names: ARNT-interacting protein, HIF-1-alpha, HIF1-alpha, HIF1A_MOUSE, Hypoxia-inducible factor 1-alpha
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q61221
Length: 279
Pfam Domains:    65-123 PAS fold
  189-269 PAS fold
  190-258 PAS fold
  191-267 PAS domain
Sequence: 
(in bold interface residues)		   1 SERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLD   60
  61 CFYLKALDGFVMVLTDDGDMVYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLT  120
 121 TQRSFFLRMKCTLTRTMNIKSATWKVLHCTGHIHCLVLICEPIPHPSNIESKTFLSRHSL  180
 181 DMKFSYCDITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAK  240
 241 RGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHD
Interface Residues: 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 140, 144, 154, 155, 158
3D-footprint Homologues: 4zpr_B, 1a0a_B, 7xhv_B, 4zpk_A, 5nj8_D, 7xi3_A, 4zpk_B, 5sy7_B, 4h10_A, 7xi3_B, 5v0l_A, 4h10_B, 8osl_O, 5nj8_C, 1s40_A
Binding Motifs: 4zpr_AB gCACGt
Binding Sites: 4zpr_C
4zpr_D
			
Publications: Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors. Nature 524:303-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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