Transcription Factor
| Accessions: | POU3F2 (HT-SELEX2 May2017) |
| Names: | ENSG00000184486, POU3F2 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: POU experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: POU experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: POU experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: POU experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 438 |
| Pfam Domains: | 261-334 Pou domain - N-terminal to homeobox domain 353-409 Homeobox domain |
| Sequence: (in bold interface residues) | 1 TAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWI 60 61 TALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPG 120 121 ALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMG 180 181 ASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPP 240 241 PPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNV 300 301 FSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIE 360 361 VSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGA 420 421 EDVYGGSRDTPPHHGVQT |
| Interface Residues: | 286, 302, 303, 304, 305, 307, 308, 314, 318, 351, 353, 354, 355, 356, 394, 395, 397, 398, 401, 402, 405, 406, 409 |
| 3D-footprint Homologues: | 3d1n_M, 7u0g_M, 3l1p_A, 2xsd_C, 1e3o_C, 7xrc_C, 1au7_A, 1o4x_A, 8g87_X, 3lnq_A, 1ig7_A, 6a8r_A, 5zfz_A, 1fjl_B, 3cmy_A, 2h1k_B, 5zjt_E, 1puf_A, 1jgg_B, 1nk2_P, 1zq3_P, 2lkx_A, 2ld5_A, 5hod_A, 1puf_B, 4xrs_G, 3a01_E, 1b72_A, 3rkq_B, 2r5y_A, 5jlw_D, 7q3o_C, 1le8_A, 2hdd_A, 1mnm_C, 1du0_A, 4cyc_A, 6es3_K, 1k61_B, 7psx_B, 5flv_I |
| Binding Motifs: | POU3F2_10 TAATkagsmwvhTmATtA POU3F2_6 wTATGCwAATkag POU3F2_7 mTAATTTATGCrt POU3F2_8 wTAATGAkATGCrw POU3F2_9 wtATGCrCATaa POU3F2_methyl_1 wTATGCwAATkAG POU3F2_methyl_2 wTAATTTATGCGy POU3F2_methyl_3 wTAATGAkATGCGy POU3F2_methyl_4 dtATGCGCATaw POU3F2_methyl_5 TAATkAggtgsTAATkA |
| Related annotations: | PaperBLAST |
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