Transcription Factor

						

			
Accessions: TFAP2A_DBD (HumanTF 1.0)

			
Names: Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2 transcription factor, AP2-alpha, AP2A_HUMAN, TFAP2A, Transcription factor AP-2-alpha
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: P05549
Notes: Ensembl ID: ENSG00000137203; DNA-binding domain sequence; TF family: AP2; Clone source: Gene synthesis
Length: 225
Pfam Domains:     3-209 Transcription factor AP-2
Sequence: 
(in bold interface residues)		   1 VNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRS   60
  61 LREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQ  120
 121 HSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISH  180
 181 GFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNAKSS
Interface Residues: 18, 52, 53
3D-footprint Homologues: 8j0k_B
Binding Motifs: TFAP2A_DBD_1 ysCCCyvrGGCa
TFAP2A_DBD_2 hGCCysAGGCw
TFAP2A_DBD_3 wsCCcybrgGGSa
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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