Transcription Factor
| Accessions: | UP00231A (UniPROBE 20160601) |
| Names: | Homeobox protein NK-2 homolog B, Homeobox protein Nkx-2.2, locus 2 (Drosophila), NK2 transcription factor related, Nkx2-2, Nkx2.2, Nkx2b, tinman |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P42586 |
| Description: | NK2 transcription factor related, locus 2 (Drosophila) |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 DNDKETQGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQV 60 61 KIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAV |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 6a8r_A, 3cmy_A, 1puf_A, 3d1n_M, 5zfz_A, 1fjl_B, 1ig7_A, 2lkx_A, 1zq3_P, 1nk2_P, 7q3o_C, 6es3_K, 2ld5_A, 3lnq_A, 2hdd_A, 1jgg_B, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 1au7_A, 6m3d_C, 5flv_I, 3l1p_A, 5zjt_E, 1b72_A, 3a01_E, 2h1k_B, 7psx_B, 5jlw_D, 1e3o_C, 7xrc_C, 1le8_A, 2xsd_C, 4j19_B, 1o4x_A, 1du0_A, 4qtr_D, 4cyc_A, 8g87_X, 5hod_A |
| Binding Motifs: | UP00231A_1 hwarCCACTTGArawtw |
| Binding Sites: | AAGTACTC AAGTACTT ACACTTGA ACTTGAGA ATAAGTGG CACTTAAG CACTTCAA CACTTGAA CACTTGAC CACTTGAG CCACTCGA CCACTTAA CCACTTCA CTCAAGTA GAGTACTC GCACTTAA GCACTTGA GTACTTCA GTACTTGA TAAGTGGA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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