Transcription Factor
| Accessions: | GLI1_MOUSE (HOCOMOCO 10), P47806 (JASPAR 2024) |
| Names: | GLI1_MOUSE, Glioma-associated oncogene homolog, Zinc finger protein GLI1 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P47806 |
| Length: | 1111 |
| Pfam Domains: | 271-298 Zinc finger, C2H2 type 291-316 Zinc-finger double domain 304-328 C2H2-type zinc finger 304-328 Zinc finger, C2H2 type 320-347 Zinc-finger double domain 335-359 C2H2-type zinc finger 353-377 Zinc-finger double domain 365-390 C2H2-type zinc finger 365-390 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETS 60 61 SCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSP 120 121 GGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATC 180 181 QLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDC 240 241 RWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTG 300 301 EKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHS 360 361 NEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKRE 420 421 REGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDL 480 481 SSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVS 540 541 LDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARG 600 601 SGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFK 660 661 SLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLN 720 721 PYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPEN 780 781 WGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSE 840 841 GSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLV 900 901 CNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPA 960 961 SANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPE 1020 1021 VGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTP 1080 1081 SPSGPPNMAVGNMSVLLGSLPGETQFLNSSA |
| Interface Residues: | 251, 253, 254, 257, 281, 283, 286, 287, 288, 289, 290, 292, 293, 295, 296, 299, 316, 317, 318, 319, 320, 321, 322, 323, 346, 347, 348, 349, 350, 351, 352, 353, 354, 357, 378, 379, 380, 381, 382, 383, 384, 385, 408, 410, 411, 418 |
| 3D-footprint Homologues: | 5ei9_F, 7w1m_H, 1ubd_C, 5yel_A, 6blw_A, 8cuc_F, 1tf3_A, 6jnm_A, 3uk3_C, 2gli_A, 1tf6_A, 6ml4_A, 5v3j_F, 5k5i_A, 6e94_A, 7ysf_A, 6a57_A, 2jpa_A, 5kkq_D, 8ssq_A, 8ssu_A, 7y3l_A, 2kmk_A, 1llm_D, 6u9q_A, 8h9h_G, 7n5w_A, 5yj3_D, 4x9j_A, 1f2i_J, 5kl3_A, 7txc_E, 1g2f_F, 2lt7_A, 7y3m_I, 2drp_D, 2wbs_A, 4m9v_C |
| Binding Motifs: | GLI1_MOUSE.H10MO.C|M01128 sTGGGTGGTCy MA1990.1 mvrGACCACCCAsr MA1990.2 rGACCACCCA |
| Binding Sites: | MA1990.1.1 / MA1990.1.2 MA1990.1.10 / MA1990.1.14 MA1990.1.11 / MA1990.1.16 MA1990.1.12 / MA1990.1.19 MA1990.1.13 MA1990.1.14 MA1990.1.15 MA1990.1.16 MA1990.1.17 MA1990.1.18 MA1990.1.19 MA1990.1.2 / MA1990.1.3 MA1990.1.20 MA1990.1.3 / MA1990.1.4 MA1990.1.4 / MA1990.1.8 MA1990.1.5 MA1990.1.6 MA1990.1.7 / MA1990.1.9 MA1990.1.12 / MA1990.1.8 MA1990.1.13 / MA1990.1.9 MA1990.1.1 MA1990.1.10 MA1990.1.11 MA1990.1.15 MA1990.1.17 MA1990.1.18 MA1990.1.20 MA1990.1.5 MA1990.1.6 / MA1990.1.7 MA1990.2.1 / MA1990.2.2 MA1990.2.10 MA1990.2.11 / MA1990.2.16 / MA1990.2.4 MA1990.2.12 MA1990.2.13 MA1990.2.14 / MA1990.2.19 / MA1990.2.3 / MA1990.2.9 MA1990.2.15 / MA1990.2.8 MA1990.2.17 MA1990.2.18 MA1990.2.20 MA1990.2.5 MA1990.2.6 MA1990.2.7 |
| Publications: | Infante P, Mori M, Alfonsi R, Ghirga F, Aiello F, Toscano S, Ingallina C, Siler M, Cucchi D, Po A, Miele E, D'Amico D, Canettieri G, De Smaele E, Ferretti E, Screpanti I, Uccello Barretta G, Botta M, Botta B, Gulino A, Di Marcotullio L. Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. EMBO J 34:200-17 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.